Table 3. Minimum inhibitory concentrations (MIC) (μg/mL) of tested antimicrobials against tested B. pseudomallei and B. mallei strains.
Strain no. | Species | Amoxicillin/clavulanic acid ≤8/4 Sa,16/8 Ib and ≥32/16 Rc | Ampicillin/sulbactam ≤8/4 S, 16/8 I and ≥32/16 R | Ceftazidime ≤8 S, 16 I and ≥32 R | Chloramphenicol ≤8 S, 16 I and ≥32 R | Ciprofloxacin ≤1 S, 2 I and ≥4 R | Doxycycline ≤4 S, 8 I and ≥16 R | Imipenem ≤4 S, 8 I and ≥16 R | Piperacillin ≤16 S, 32-64 I and ≥128 R | trimethoprim-sulfamethoxazole ≤2/38 S, ≥4/76 R | Meropenem ≤4 S, 8 I and ≥16 R | Tigecycline ≤4 S, 8 I and ≥16 R |
---|---|---|---|---|---|---|---|---|---|---|---|---|
BM1343 | B. mallei | 0.75 | 1.5 | 0.75 | 0.5 | 0.23 | 0.064 | 0.125 | 1 | 0.23 | 0.125 | 0.125 |
BM1345 | B. mallei | 0.75 | 3 | 4 | >256 | 8 | 2 | 0.25 | 3 | >32 | 0.125 | 4 |
BM1347 | B. mallei | 0.5 | 1.5 | 0.75 | 1 | 0.25 | 0.047 | 0.125 | 4 | <0.002 | 0.064 | 0.125 |
BM1349 | B. mallei | 1 | 1.5 | 1.5 | 12 | 1.5 | 0.32 | 0.125 | 1.5 | <0.002 | 0.064 | 0.19 |
BM1352 | B. mallei | 3 | 4 | 2 | 3 | 0.25 | 0.064 | 0.19 | 3 | 0.016 | 0.125 | 0.094 |
BM1354 | B. pseudomallei | 3 | 4 | 0.75 | 8 | 1.5 | 3 | 0.5 | 0.5 | 1.5 | 0.5 | 16 |
BM1355 | B. pseudomallei | 1 | 2 | 0.5 | 1 | 3 | 0.25 | 0.38 | 1.5 | 2 | 0.5 | 1.5 |
BM1357 | B. pseudomallei | 3 | 4 | 1 | 8 | 3 | 1.5 | 0.25 | 2 | 0.25 | 0.38 | 6 |
BM1360 | B. pseudomallei | 1 | 1.5 | 0.5 | 16 | 4 | 2 | 0.19 | 1 | 1 | 0.38 | 4 |
BM1361 | B. pseudomallei | 12 | 3 | 0.75 | 48 | 6 | 4 | 1 | 1.5 | 1 | 0.5 | 32 |
BM649 | B. pseudomallei | 4 | 8 | 1.5 | 12 | 8 | 1.5 | 0.38 | 2 | 1.5 | 0.75 | 24 |
a S) susceptible; indicates there is a high probability of a favorable treatment outcome when treated with this antimicrobial(s)
b(I) Intermediate susceptible; indicates a uncertain outcome when treated with this antimicrobial(s)
c(R) Resistant, which indicates there is a low probability of a favorable treatment outcome when treated with this antimicrobial(s) (45).