Table 1.
Demographic and clinical characteristics of the 205 HD patients.
Age of Motor Symptom Onset (Years) | CAG Repeats | Age at Diagnosis (Years) | DD (Years) | Duration (Years) | ||||||
---|---|---|---|---|---|---|---|---|---|---|
Mean (SD) | Range | Mean (SD) | Range | Mean (SD) | Range | Mean (SD) | Range | Mean (SD) | Range | |
Total (n = 205) | 41.8 (10.0) | 17–69 | 45.2 (4.5) | 38–67 | 45.7 (11.1) | 18–78 | 4.3 (3.8) | 0–20 | 5.2 (3.9) | 0–20 |
Male (n = 84) | 42.1 (10.5) | 18–67 | 45.2 (4.7) | 38–67 | 46.6 (11.6) | 22–78 | 4.7 (4.1) | 0–18 | 5.5 (4.1) | 0–18 |
Female (n = 121) | 41.6 (9.6) | 17–69 | 45.2 (4.4) | 38–61 | 45.2 (10.7) | 18–74 | 4.0 (3.6) | 0–20 | 5.1 (3.7) | 0–20 |
Juvenile HD (n = 4) | 18.1 (1.40) | 17–20 | 53.5 (12.40) | 43–67 | 22.10 (3.1) | 18–25 | 4.0 (2.0) | 1–5 | 4.50 (1.0) | 3–5 |
Adult HD (n = 193) | 41.4 (8.6) | 20–58 | 45.1 (4.2) | 38–61 | 45.3 (9.80) | 19–70 | 4.1 (3.6) | 0–19 | 5.2 (3.7) | 0–19 |
Elderly-onset HD (n = 8) | 63.5 (3.1) | 61–69 | 43.0 (1.2) | 42–45 | 68.2 (5.4) | 62–78 | 7.4 (7.3) | 1–20 | 7.4 (7.3) | 1–20 |
Positive family history (n = 162) | 40.1 (9.4) a | 17–67 | 45.7 (4.6) b | 38–67 | 43.6 (10.1) d | 18–69 | 3.8 (3.4) e | 0–19 | 4.8 (3.5) f | 0–19 |
Paternal inheritance (n = 86) | 38.9 (9.7) | 17–67 | 46.4 (5.2) | 39–67 | 42.2 (10.2) | 18–69 | 3.3 (2.8) | 0–12 | 4.38 (2.9) | 0–15 |
Maternal inheritance (n = 76) | 41.4 (9.0) | 19–62 | 44.9 (3.8) | 38–57 | 45.1 (9.8) | 19–69 | 4.4 (4.0) | 0–19 | 5.2 (4.0) | 0–19 |
Negative family history (n = 43) | 48.4 (9.4) a | 28–69 | 43.2 (3.3) b | 38–53 | 53.9 (10.7) d | 31–78 | 5.8 (4.8) e | 0–20 | 7.0 (4.8) f | 1–20 |
Motor (n = 188) | 41.4 (9.7) | 17–67 | 45.2 (4.5) c | 38–67 | 45.5 (10.8) | 18–78 | 4.2 (3.7) | 0–19 | 5.2 (3.8) | 0–19 |
Cognitive (n = 5) | 49.6 (7.5) | 42–62 | 43.4 (1.1) c | 42–45 | 50.1 (7.2) | 42–62 | 3.8 (1.4) | 2–6 | 3.7 (1.4) | 2–6 |
Psychiatric (n = 12) | 45.6 (13.5) | 25–69 | 45.8 (5.8) | 40–57 | 47.8 (15.3) | 19–73 | 5.9 (6.0) | 0–20 | 6.9 (5.4) | 0–20 |
a–f: statistically significant was found between the groups (p < 0.05). DD: diagnostic delay; SD: standard deviation.