Table 10.

Meta-analyses of MDA studies in OSA adults.

Authors	Material	Conclusion
Comparison to the control group
Fadaei et al., 2020 [114]	14 studies, 867 cases, 429 controls	MDA serum concentration significantly increased in OSA patients compared to the controls (SMD (95% CI): 1.18 (0.68, 1.68), p < 0.0001).
Change after treatment
Chen et al., 2020 [115] Fadaei et al., 2020 [116]	10 studies, 220 cases 13 studies, 606 cases	A significant decrease in serum or plasma MDA was observed after CPAP treatment (SMD = 1.164, 95% CI = 0.443 to 1.885, z = 3.16, p = 0.002). CPAP therapy significantly reduced MDA levels in OSA patients (SMD −1.51 (95% CI, −2.06 to 0.97), p < 0.05).

Abbreviations: MDA, malondialdehyde; OSA, obstructive sleep apnea; CPAP, continuous positive airway pressure.