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. 2023 Jan 6;9(1):eade1694. doi: 10.1126/sciadv.ade1694

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Fig. 10. — CDC25/CDK2 phosphorylate AR and contribute to toxicity in vitro and in vivo, whereas CaN removes phospho-marks in response to calcium signaling, thus modifying subcellular localization, function, and toxicity. CDK2 triggers a stress response in the brainstem, and its loss of function reduces polyQ-expanded AR phosphorylation and attenuates neurodegeneration.