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. 2023 Jan 6;9(1):eade1694. doi: 10.1126/sciadv.ade1694

Fig. 7. Silencing Drosophila orthologs of CDC25/CDK2 and CaN modifies the eye phenotype of flies modeling SBMA.

Fig. 7.

Top: Representative images of the ommatidia of flies expressing AR0Q (top row) or AR52Q (bottom row) with and without the indicated RNAi under the GMR promoter to drive expression in the eye (n = 15 to 20 flies per genotype). Bottom: Cdc25, Cdk2, and CaN mRNA transcript levels in flies overexpressing AR52Q with scramble or target RNAi (n = 3 flies per genotype). Disease severity scores (a function of ommatidial fusion, bristle disorganization, and depigmentation) in flies overexpressing AR52Q with and without the indicated RNAi (n = 15 to 20 flies per genotype). Graphs show means ± SEM, two-tailed Student’s t test (left), and one-way ANOVA followed by Tukey’s HSD test (right).