Fig. 6. Conditional deletion of Nrxn2 in the hippocampus of adolescent mice selectively impairs spatial reversal learning.

(A to F) The conditional Nrxn2 deletion in the hippocampal formation at P24 has no effect on the mouse behavior in the open-field test, arguing against a global disruption in brain function. (G to J) Behavioral assays show that the conditional deletion of Nrxn2 in the hippocampus does not impair acquisition of spatial memory in the water T-maze test. For more assays, see fig. S7. (K to N) Conditional deletion of Nrxn2 in the hippocampus induces a significant impairment in spatial reversal learning in the water T-maze test, suggesting an inability in relearning a new spatial situation. Data are means ± SEM; the numbers of mice analyzed are listed in the graphs. Statistical assessments were performed by two-way ANOVA (G to I and K to M) or Mann-Whitney test (A to F, J, and N) comparing the Cre condition to the ΔCre controls, with *P < 0.05 and **P < 0.01