Aβ	Amyloid-β
AD	Alzheimer’s disease
ADME	Absorption Distribution Metabolism Excretion
APP	Amyloid precursor protein
ATP	Adenosine triphosphate
BBB	Blood-brain barrier
BNAH	N-Benzyl-1,4-dihydronicotinamide
BOILED-egg	Brain or intestinal estimated permeation
CDC2	Cell division control 2 kinase
CDI	1,1′-carbonyldiimidazole
CDK	Cyclin-dependent kinase
ChemPLP	Piecewise linear potential
CLK	CDC-like kinase
CLK1	CDC-like kinase 1
CLK2	CDC-like kinase 2
CLK3	CDC-like kinase 3
CLK4	CDC-like kinase 4
cLogP	Calculated LogP
CMGC	CDK, MAPKK, GSK3, CLK group of kinases
CNS	Central nervous system
DMF	Dimethylformamide
DMSO	Dimethylsulfoxide
DPPH•	2,2-diphenyl-1-picrylhydrazyl
DYRK	Dual-specificity tyrosine phosphorylation kinase
DYRK1A	Dual-specificity tyrosine phosphorylation kinase 1A
EC50	Half maximal effective concentration
EGCG	Epigallocatechin-3-gallate
ESI	Electrospray ionization
EWG	Electron withdrawing group
Glu	Glutamic acid
GOLD	Genetic optimization for ligand docking
GSK3	Glycogen synthase kinase 3
hCLK1	Human CDC-like kinase 1
hDYRK1A	Human dual-specificity tyrosine phosphorylation kinase 1A
HRMS	High resolution mass spectroscopy
IC50	Half maximal inhibitory concentration
ID	Identification code
INDY	Inhibitor of DYRK kinases
Leu	Leucine
Lys	Lysine
MAPK	Mitogen-activated protein kinase
NAD+	Nicotinamide adenine dinucleotide
NMR	Nuclear magnetic resonance
PAMPA-BBB	Parallel artificial membrane permeability assay of blood-brain barrier
PBS	Phosphate-buffered saline
PDB	Protein data bank
proINDY	Proinhibitor of DYRK kinases
PyMOL	Python Molecular modelling
rt	Room temperature
SAR	Structure-activity relationship
SR	Serine/Arginine rich proteins
T3P	Propylphosphonic anhydride
Tau	Tubulin-associated unit
Thr	Threonine
TLC	Thin layer chromatography
TMSCl	Chlorotrimethylsilane
TPSA	Topological polar surface area
UV	Ultraviolet
WLOGP	Wildman-Crippen LogP