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. 2022 Dec 27;24(12):e40035. doi: 10.2196/40035

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©Emily Jefferson, Christian Cole, Shahzad Mumtaz, Samuel Cox, Thomas Charles Giles, Sam Adejumo, Esmond Urwin, Daniel Lea, Calum Macdonald, Joseph Best, Erum Masood, Gordon Milligan, Jenny Johnston, Scott Horban, Ipek Birced, Christopher Hall, Aaron S Jackson, Clare Collins, Sam Rising, Charlotte Dodsley, Jill Hampton, Andrew Hadfield, Roberto Santos, Simon Tarr, Vasiliki Panagi, Joseph Lavagna, Tracy Jackson, Antony Chuter, Jillian Beggs, Magdalena Martinez-Queipo, Helen Ward, Julie von Ziegenweidt, Frances Burns, Joanne Martin, Neil Sebire, Carole Morris, Declan Bradley, Rob Baxter, Anni Ahonen-Bishopp, Paul Smith, Amelia Shoemark, Ana M Valdes, Benjamin Ollivere, Charlotte Manisty, David Eyre, Stephanie Gallant, George Joy, Andrew McAuley, David Connell, Kate Northstone, Katie Jeffery, Emanuele Di Angelantonio, Amy McMahon, Mat Walker, Malcolm Gracie Semple, Jessica Mai Sims, Emma Lawrence, Bethan Davies, John Kenneth Baillie, Ming Tang, Gary Leeming, Linda Power, Thomas Breeze, Duncan Murray, Chris Orton, Iain Pierce, Ian Hall, Shamez Ladhani, Natalie Gillson, Matthew Whitaker, Laura Shallcross, David Seymour, Susheel Varma, Gerry Reilly, Andrew Morris, Susan Hopkins, Aziz Sheikh, Philip Quinlan. Originally published in the Journal of Medical Internet Research (https://www.jmir.org), 27.12.2022.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in the Journal of Medical Internet Research, is properly cited. The complete bibliographic information, a link to the original publication on https://www.jmir.org/, as well as this copyright and license information must be included.

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The CO-CONNECT federated architecture. A data partner (dark box) has potentially identifiable data (A) from which an extraction is made and pseudonymized (B). A metadata extraction is performed with WhiteRabbit (within the identifiable Data Zone, red box) and sent to the CO-CONNECT infrastructure (green box). A mapping script to the OMOP CDM is created using the CO-CONNECT data mapping tool (CaRROT-Mapper). The pseudonymized data are securely transferred (B) into a secure virtual machine hosted by the data partner (Federated Node, dashed dark box), mapped to OMOP (CaRROT-CDM), and connected to the federation software (C and D). From there, the data are queryable by the Innovation Gateway (E). Only aggregated fully anonymous data discovery and meta-analysis results are returned to the Gateway (D). CDM: Common Data Model; OMOP: Observational Medical Outcomes Partnership.