Table 2.
Functional modulation of Piezo1 in cancer.
| Disease | Target | Mechanism | Effect on Disease/Clinical |
|---|---|---|---|
| Stomach cancer | TFF1 | TFF1, which binds and colocalizes Piezo1 in the cytosol, mediates migration of cancer cells in the gastric cavity | Piezo1 regulates the proliferation, migration, and invasion of stomach tumors [34] |
| Colon tumors | HIF-1α | Piezo1-MCU-HIF-1α-VEGF signaling axis mediates the metastasis of colon cancer cells | Overexpression of Piezo1 promotes the migration of colon cancer cells [36] |
| Hepatocellular carcinoma | JNK p38 ERK |
The Piezo1-MAPK-YAP signaling pathway may inhibit the growth of hepatocellular tumors | Absence of Piezo1 promotes the proliferation, migration, and apoptosis of liver cancer cells [37] |
| Lung cancer | Piezo2 | The mRNA expression of Piezo1 and Piezo2 is significantly lower in tumor tissues of non-small cell lung cancer (NSCLC) | Piezo1 in NLCLC could significantly stimulate the migration of tumor cells in vitro and the growth of tumors in vivo [38,39] |
| Breast carcinoma | Ezrin, radixin and moesin (ERM) | Piezo1 activation inhibits thrombin induced phosphorylation of ERM | Piezo1 is an inhibitor of thrombinase-induced blistering in breast cancer cells [40] |
| Oral squamous cell carcinoma (OSCC) | Yes-associated protein YAP | The organism promotes OSCC cell growth through the YAP-Piezo1 signaling pathway | Upregulation of Piezo1 expression is necessary for OSCC cell proliferation [41] |
| Pancreatic ductal adenocarcinoma | Rb1 | Piezo1 inhibits Rb1 expression by regulating histone decarboxylase 2 | Elimination of Piezo1 in myeloid cells could prevent cancer [42] |
Functional relevance of Piezo1 in cancer. In recent years, a number of studies have shown that Piezo1 plays an important role in regulating the occurrence and development of various tumors, such as stomach cancer [34], colon tumors [36], hepatocellular carcinoma [37], lung cancer [38,39], breast carcinoma [40], oral squamous cell carcinoma [41], and pancreatic ductal adenocarcinoma [42]. Table 2 shows various signaling pathways related to the induction of key regulators of Piezo1 channel proteins, in response to mechanical stimulation, which provides new research ideas for subsequent tumor treatment.