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. 2022 Nov 15;11:e80927. doi: 10.7554/eLife.80927

Appendix 1—table 3. Comparison of different variance estimators.

Mean and 95% confidence intervals calculated from bootstrap distributions of 10,000 re-samplings with replacement for each dataset used in this work. The estimators are obtained as follows: bare variance is computed using all available cells that could be put in the required family pair (Materials and methods - ‘Data analysis and Bayesian inference of theinheritance matrix model’). The lineage variance is calculated through the weighted variance with weights wi=2-Di/Ntrees following arguments similar to Priestman et al., 2017; Nozoe et al., 2017. Here Di is the number of divisions in the lineage that came before cell i and Ntrees is the total number of trees in the whole dataset. The censored variance is calculated after pruning trees such that each tree contains lineages of the same length as in Kuchen et al., 2020; Sandler et al., 2015.

Cell type Bare variance (hours2) Lineage variance (hours2) Censored variance (hours2)
Cyanobacteria (S. elongatus) 10.674 [9.966, 11.396] 11.543 [10.420, 12.776] 10.612 [9.850, 11.391]
Clock deleted cyanobacteria
(S. elongatuskaiBC )
3.573 [3.288, 3.865] 4.015 [3.529, 4.512] 3.485 [3.176, 3.805]
Mycobacteria (M. smegmatis) 0.427 [0.366, 0.494] 0.601 [0.490, 0.716] 0.609 [0.492, 0.738]
Human colorectal cancer (HCT116) 6.489 [4.540, 8.809] 7.357 [4.898, 10.262] 6.741 [4.695, 9.124]
Neuroblastoma (TET21N) 9.794 [8.539, 11.213] 13.986 [10.735, 17.775] 10.502 [8.554, 12.621]
Mouse embryonic fibroblasts (NIH3T3) 37.032 [29.260, 46.162] 46.378 [34.494, 60.090] 39.418 [29.947, 50.219]