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. 2022 Dec 14;11:e80949. doi: 10.7554/eLife.80949

Figure 2. Expression of pathologic hypertrophy markers and cardiac myocyte sizes in LV of TGAC8 and WT mice.

(A) WB of Pathologic hypertrophy markers, (B, C) cardiac myocyte cross-sectional areas and distributions of cardiac myocyte sizes in TGAC8 and WT hearts (cardiomyocytes were counted on left free wall at the middle level sections from four animals in each group; 37 high power fields from WT mice and 33 high power fields from TGAC8 mice; 77 cells from WT mice and 70 cells from TGAC8 mice were analyzed) Data are presented as Mean± SEM. The statistical significance is indicated by * p<0.05, ** p<0.01, (two-tailed t test)., (D) Representative LV sections depicting cardiac myocyte diameters (scale bar 100 µm).

Figure 2—source data 1. Raw unedited blot images and uncropped blot images of MYH7, α Sk.
Actin, ANP, BNP, and Calcineurin.

Figure 2.

Figure 2—figure supplement 1. Representative LV sections, labeled with picrosirius red (A) and (B) average collagen density (picrosirius red labeling) in TGAC8 vs WT LV.

Figure 2—figure supplement 1.

Scale bar 100 µm. N=37 high power fields of left free wall at the middle level from four WT mice. N=33 high power fields of left free wall at the middle level from four TGAC8 mice. Data are presented as Mean± SEM.