Table 4.
Annonacin toxicity prediction.
| ADMETLab | |
| hERG | Negative |
| hepatotoxicity | Negative |
| skin sensitization | Negative |
| Reduction of liver damage | Negative |
| AMES | Negative |
| PreADME | |
| Algae | Toxic |
| Medaka sp. | Very toxic |
| Daphnia | Toxic |
| Minnow | Toxic |
| Ames | Negative |
| Carcinogenic (rats) | Negative |
| Carcinogen (mice) | Positive |
| hERG | Negative |
| Osiris | |
| Mutagen | Negative |
| Tumorigenic | Negative |
| Irritating | Negative |
| Effect on reproduction | Negative |
| ProTox | |
| Hepatotoxicity | Negative |
| Carcinogenicity | Negative |
| Immunogenicity | Positive |
| Mutagenicity | Negative |
| Cytotoxicity | Positive |
Source: Authors.