Table 2.

Synthesis route of the target compounds 1a–l and 2a–l.

Ar	For Compounds 3		For Compounds 1, 2 and 6
			Het—4-methyl-1,2,3-thiadiazolyl (1a–l, 6a)		Het—3,4-dichloro-isothiazolyl (2a–l, 6b)
	Comp.	Yield, %	Comp.	Yield, %	Comp.	Yield, %
C6H5	3a	92	1a	73	2a	71
3-MeC6H4	3b	76	1b	74	2b	90
4-MeC6H4	3c	79	1c	68	2c	75
2,6-(Me)2C6H3	3d	88	1d	69	2d	72
2,4,6-(Me)3C6H2	3e	58	1e	82	2e	77
3-ClC6H4	3f	76	1f	97	2f	97
4-ClC6H4	3g	78	1g	87	2g	91
3,5-Cl2C6H3	3h	53	1h	86	2h	59
2-Me-3-ClC6H3	3i	73	1i	75	2i	67
3-MeOC6H4	3j	74	1j	80	2j	84
4-MeOC6H4	3k	61	1k	86	2k	82
3-CF3C6H4	3l	89	1l	96	2l	61