Table 1.
Biochemically characterized plant natural product methyltransferases.
| Name | Plant Species | Acceptor | PNPMT Class | Pathway/Substrate Class | Accepted Substrate | Nucleotide Accession Number | Protein Accession Number | PDB | Ref |
|---|---|---|---|---|---|---|---|---|---|
| ALKALOIDS | |||||||||
| Cj4’OMT | Coptis japonica | O | OMT | benzylisoquinoline | (R,S)-laudanosoline, (R,S)-6-O-methylnorlaudanosoline, (R,S)-norlaudanosoline, (S)-scoulerine | D29812 | BAB08005 | [34] | |
| Cj6OMT | Coptis japonica | O | OMT | benzylisoquinoline | (R,S)-norococlaurine, (R,S)-6-O-methylnorlaudanosoline, (R,S)-laudanosoline, (R,S)-norlaudanosoline, laudanosoline, (S)-scoulerine | D29811 | BAB08004 | [34] | |
| CjCNMT | Coptis japonica | N | NMT | benzylisoquinoline | (R,S)-coclaurine, (R,S)-norreticuline, (R,S)-norlaudanosoline, (R,S)-6-O-methylnorlaudanosoline, 6,7-dimethoxyl-1,2,3,4-tetrahydroisoquinoline, 1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinolinne | AB061863 | BAB71802 | 6GKZ | [35,36] |
| PSMT1 | P. somniferum | O | OMT | benzylisoquinoline | scoulerine | JQ658999 | AFB74611 | 6I5Z | [37] |
| PsN7OMT | P. somniferum | O | OMT | benzylisoquinoline | (S)-norreticuline | FJ156103 | ACN88562 | [38] | |
| PsSOMT1-3 | P. somniferum | O | OMT | benzylisoquinoline | (S)-scoulerine, (S)-tetrahydrocolumbamine, (S)-norreticuline, (S)-reticuline |
JN185323 (1) JN185324 (2) JN185325 (3) |
AFK73709 (1) AFK73710 (2) AFK73711 (3) |
[39] | |
| SiSOMT | Stephania intermedia | O | OMT | benzylisoquinoline | (S)-scoulerine, (S)-tetrahydropalmatrubine, (S)-tetrahydrocolumbamine | MK749415 | QFU85196 | [40] | |
| SiCNMT1-3 | Stephania intermedia | N | NMT | benzylisoquinoline | (R)-coclaurine |
MK749412 MK749413 MK749414 |
QFU85193 QFU85194 QFU85195 |
[40] | |
| St6OMT1 | Stephania tetrandra | O | OMT | benzylisoquinoline | (S)-norcoclaurine | [41] | |||
| NnOMT1,5 | Nelumbo nucifera | O | OMT | benzylisoquinoline | 1-benzylisoquinolines |
XM_010245752 XM_010249599 XM_010249600 XM_010273389 XM_010277761 |
XP_010244054 XP_010247901 XP_010247902 XP_010271691 XP_010276063 |
[42] | |
| PsRNMT | Papaver somniferum | N | NMT | benzylisoquinoline | (R)-reticuline, (S)-reticuline, papaverine, (R,S)-tetrahydropapaverine, boldine, (S)-corytuberine, (+)-isothebaine, (+)-isocorydine, (+)-glaucine, (+)-bulbocapnine, narcotine hemiacetal, noscapine, hydrastine | KX369612 | AOR51552 | [43] | |
| PsTNMT | P. somniferum | N | NMT | benzylisoquinoline | (R,S)-canadine, (R,S)-tetrahydropalmatine, (R,S)-stylopine | DQ028579 | AAY79177 | [44] | |
| TfPavNMT | Thalictrum flavum | N | NMT | benzylisoquinoline | (S)-reticuline, pavine, (R,S)-tetrahydropapaverine, (R,S)-scoulerine, (R,S)-stylopine | EU883010 | ACO90251 | 5KOK | [45] |
| GfTNMT | Glaucium flavum | N | NMT | benzylisoquinoline | (S)-stylopine, tetrahydropalmatine, (S)-canadine, (S)-tetrahydrocolumbamine, (S)-scoulerine | 6P3O | [46] | ||
| TtOMTI (Thatu OMT II;1.1) | Thalictrum tuberosum | O | OMT | benzylisoquinoline | caffeic acid, catechol, guajacol, ferulic acid, sinapic acid, (S)-norcoclaurine, (S)-norlaudanosoline, (R,S)-3ʹ-O-methylnorlaudanosoline, (R,S)-4ʹ-O-methylnorlaudanosoline, (R,S)-laudanosoline, (S)-4ʹ-O-methyllaudanosoline, (S)-nororientaline, (R)-nororientaline, (R,S)-norisoorientaline, (S)-reticuline, (R,S)-3-O-demethylcheilanthifoline, (S)-6-O-demethylautumnaline, (R)-6-O-demethylautumnaline | AF064693 | AAD29841 | [47] | |
| Ca10OMT | Camptotheca acuminata | O | OMT | monoterpene indole, flavonoid, phenolics | 10-hydroxycamptothecin, kaempferol, quercetin, kaempferol 3-OGlc, quercetin 3-O-Glc, 7-O-methylquercetin, 4ʹ-O-methylquercetin | MG996006 | AWH62806 | [48] | |
| Cr16OMT | Catharanthus roseus | O | OMT | monoterpene indole | 16-hydroxytabersonine | EF444544 | ABR20103 | [27] | |
| CrNMT | Catharanthus roseus | N | NMT | monoterpene indole | 16-methoxy- 2,3-dihydro-3-hydroxy tabersonine |
HM584929.1 | ADP00410.1 | [49] | |
| TiN10OMT | Tabernanthe iboga | O | OMT | monoterpene indole | ibogamine, noribogaine, 10-hydroxycoronaridine | MH454075 | AXF35975 (partial) | [50] | |
| VmPiNMT | Vinca minor | O | OMT | monoterpene indole | picrinine, 21-hydroxylochnericine, norajmaline | KC708450 | AHH02782 | [51] | |
| RsANMT | Rauvolfia serpentina | N | NMT | monoterpene indole | ajmaline, norajmaline | KC708445 | AHH02777 | [52] | |
| RsNNMT | Rauvolfia serpentina | N | NMT | monoterpene indole | norajmaline, Nb-methylnorajamaline | KC708449 | AHH02781 | [52] | |
| RsPiNMT | Rauvolfia serpentina | N | NMT | monoterpene indole | picrinine, 21-hydroxylochnericine, norajmaline | KC708448 | AHH02780 | [52] | |
| Vm16OMT | Vinca minor | O | OMT | monoterpene indole | 16-hydroxytabersonine | MH010798 | QBY35563 | [53] | |
| PiIpeOMT1-3 | Psychotria ipecacuanha | O | OMT | monoterpene isoquinoline | isococlaurine, N-deacetylisoipecoside, 7-O-methyl-N-deacetylisoipecoside, cephaeline, norcoclaurine, 4-O-methyllaudanosoline, nororientaline, isoorientaline, (1R) norprotosinomenine, (1S) norprotosinomenine, protosinomenine |
AB527082 (1) AB527083 (2) AB527084 (3) |
BAI79243 (1) BAI79244 (2) BAI79245 (3) |
[28] | |
| CaDXMT1 | Coffea arabica | N | NMT | purine | paraxanthine, theobromine, 7-methylxanthine | AB084125 | BAC75663 | [54] | |
| CaMXMT | C. arabica | N | NMT | purine | 7-methylxanthine, paraxanthine | AB048794 | BAB39216 | [55] | |
| CaXMT1 | C. arabica | N | NMT | purine | xanthine | AB048793 | BAB39215 | [54] | |
| CcDXMT | Coffea canephora | N | SABATH | purine | 3,7-dimethylxanthine | DQ422955 | ABD90686 | 2EFJ | [56] |
| CcXMT | Coffea canephora | N | SABATH | purine | xanthosine | DQ422954 | ABD90685 | 2EG5 | [56] |
| CmXRS1 | C. arabica | N | NMT | purine | xanthosine | AB034699 | BAC43755 | [57,58] | |
| PcCS | Paullinia cupana var. sorbilis | N | NMT | purine | theobromine, 7-methylxanthine | BK008796 | DAA64605 | [59] | |
| NpN4OMT1 | Narcissus sp. | O | OMT | phenethylamine | norbelladine, N-methylnorbelladine, dopamine | KJ584561 | AIL54541 | [29] | |
| LrOMT | Lycoris radiata | O | Cation-dependent OMT | alkaloid | norbelladine, caffeic acid, 3,4-dihyroxybenzaldehyde, dopamine, 3,4-dihydroxybenzylamine, higenamine, 1,2,3,4-4H-6,7-isoquinolinediol, (-)-epinephrine, (-)-norepinephrine, 5-hydroxyvanillin, 3,4,5-trihydroxybenzaldehyde, ethyl 3,4-dihydroxybenzoate, 4-Br-catechol, 4-F-catechol | MK805029 | QEP29044 | [60] | |
| PMT | Nicotiana tabacum | N | NMT | amine | putrescine | D28506 | BAA05867 | [61] | |
| PMT | Solanum tuberosum | N | NMT | amine | putrescine | AJ605553 | CAE53633 | [62] | |
| PMT | Calystegia sepium | N | NMT | amine | putrescine | AM177608 | CAJ46252 | [63] | |
| PMT | Datura innoxia | N | NMT | amine | putrescine |
AM177609 AM177610 |
CAJ46253 CAJ46254 |
[63] | |
| PMT | Physalis divaricata | N | NMT | amine | putrescine | AM177611 | CAJ46255 | [63] | |
| PMT | Datura stramonium | N | NMT | amine | putrescine | AJ583514 | CAE47481 | [64] | |
| PHENOLICS | |||||||||
| CdFOMT5 | Citrus depressa | O | OMT | flavonoid | quercetin, 3-hydroxyflavone, 5-hydroxyflavone, 6-hydroxyflavone, 7-hydroxyflavone, naringenin, (-)-epicatechin, equol | LC126059 | BAU51794 | [65] | |
| CrOMT2 | Catharanthus roseus | O | OMT | flavonoid | myricetin, quercetin, dihydroquercetin, dihydromyricetin | AY127568 | AAM97497 | [66] | |
| CrOMT6 | Catharanthus roseus | O | OMT | flavonoid | homoeriodictyol, isorhamnetin, chrysoeriol, quercetin, eriodictyol, kaempferol | AY343490 | AAR02420 | [67] | |
| CuCitOMT | Citrus unshiu Marc. | O | OMT | flavonoid | 3′,4′-dihydroxyflavone, 3′,4′,5,7-tetrahydroxyflavone | LC516612 | BBU25484 | [68] | |
| HvOMT1 | Hordeum vulgare | O | OMT | flavonoid | tricetin, luteolin, tricetin, quercetin, 5-hydroxyferulic acid, eriodictyol, taxifolin | EF586876 | ABQ58825 | [69] | |
| ZmOMT1 | Zea mays | O | OMT | flavonoid | luteolin, tricetin, quercetin, 5-hydroxyferulic acid, eriodictyol, taxifolin | XM_002436508 | ABQ58826 | [69] | |
| ObF8OMT-1 | Ocimum basilicum | O | OMT | flavonoid | 7,8,4ʹ-OH-flavone, 8-OH-7-OCH3-flavone, 7,8-OH-flavone, 7,8,3ʹ,4ʹ-OH-flavone | KC354402 | AGQ21572 | [70] | |
| ObFOMT1-6 | Ocimum basilicum | O | OMT | flavonoid | luteolin, apigenin, scutellarein, hispidulin, naringenin, chrysoeriol, diosmetin, acacetin, scutellarein-4ʹ-methyl ether, nevadensin, cirsimaritin, kaempferol, quercetin, scutellarein-4ʹ-methyl ether, nepetin, ladanein, cirsioliol, genkwanin, scutellarein-7-methyl ether, naringenin-7-methyl ether, scutellarein-7-O-glucuronide |
JQ653275 (1) JQ653276 (2) JQ653277 (3) JQ653278 (4) JQ653279 (5) JQ653280 (6) |
AFU50295 (1) AFU50296 (2) AFU50297 (3) AFU50298 (4) AFU50299 (5) AFU50300 (6) |
[70] | |
| ObPFOMT-1 | Ocimum basilicum | O | OMT | flavonoid | 7,8,4ʹ-OH-flavone, 7,8-OH-flavone, 6,7-OH-flavone, 5,6-OH-flavone, 5,6-OH-7-OCH3-flavone, eriodictyol, ladanein, scutellarein-7-methyl ether, scutellarein 4ʹ-methyl ether, scutellarein, scutellarin, cirsiliol, nepetin, luteolin, luteolin-7-methyl ether, luteoline-7-glucoside, quercetagetin, quercetin, quercetin-7-methyl ether, tricetin, 3ʹ,4ʹ-OH-flavone, 5,3ʹ,4ʹ-OH-flavone, 7,3ʹ,4ʹ-OH-flavone, 7,8,3ʹ,4ʹ-OH-flavone | KC354401 | AGQ21571 | [70] | |
| OsNOMT | Oryza sativa | O | OMT | flavonoid | racemic naringenin, kaempferol, apigenin, luteolin, racemic liquiritigenin, quercetin | AB692949 | BAM13734 | [71] | |
| ShMOMT3 | Solanum habrochaites | O | OMT | flavonoid | quercetin, kaempferol, myricetin, 7-methyl quercetin, 3-methyl quercetin, 3-methyl myricetin, 3ʹ,5ʹ-dimethyl myricetin, 3ʹ-methyl quercetin | KC513419 | AGK26768 | [72] | |
| SlMOMT4 | Solanum lycopersicum | O | OMT | flavonoid | myricetin, 3′-methylmyricetin | KF740343 | AIN36846 | [73] | |
| MpOMT4 | Mentha x piperita | O | OMT | flavonoid | isorhamnetin, kaempferol, quercetin, rhamnetin, luteolin, apigenin, 6-OH-apigenin, 7,8,3ʹ,4ʹ-OH-flavone, naringenin, taxifolin | AY337461 | AAR09602 | [74] | |
| PaF4’OMT | Plagiochasma appendiculatum | O | OMT | flavonoid | apigenin, luteoline, scutellarein, genkwanin, eriodictyol, naringenin, quercetin, kaempferol, genistein | KY977687 | ARS23163 | [75] | |
| ShMOMT1 | Solanum habrochaites | O | OMT | flavonoid | myricetin, quercetin, 7-methyl quercetin, 3-methyl quercetin | JF499656 | ADZ76433 | [76] | |
| ShMOMT2 | Solanum habrochaites | O | OMT | flavonoid | 7-methyl quercetin, quercetin, kaempferol, myricetin, 4ʹ-methyl kaempferol, 3,7,4ʹ-trimethyl kaempferol, 3ʹ-methyl quercetin, 3-methyl quercetin, 3,7,3ʹ,4ʹ-tetramethyl quercetin, 3ʹ-methyl myricetin, 3ʹ,5ʹ-dimethyl myricetin, 3ʹ,4ʹ,5ʹ-trimethyl myricetin | JF499657 | ADZ76434 | [76] | |
| AtCCoAOMT7 | Arabidopsis thaliana | O | OMT | flavonoid | luteolin, quercetin, caffeoyl-CoA, esculetin | At4g26220 | NP_567739 | [77] | |
| AtOMT1 | Arabidopsis thaliana | O | OMT | flavonoid | quercetin, myricetin, luteolin | U70424 | AAB96879 | [78,79] | |
| CaFOMT1 | Chrysosplenium americanum | O | OMT | flavonoid | 3,7,4ʹ-triOMeQ, 2ʹ-OH 3,6,7,4ʹ-tetraOMeQg, 2ʹ-OH 3,7,4ʹ-triOMeQ, 3,6,7,4ʹ-tetraOMeQg; Abbreviations: Q, quercetin; Qg, quercetagetin (6-OH-Q) | U16794 | AAA80579 | [80] | |
| CaOMT2 | Chrysosplenium americanum | O | OMT | flavonoid | quercetin, luteolin, 5-hydroxyferulic, caffeic acid | U16793 | AAA86982 | [81] | |
| OsCAldOMT1 | Oryza sativa | O | OMT | flavonoid | 5-hydroxyconiferaldehyde, selgin | Q6ZD89 | [82] | ||
| VvOMT1-2 | Vitis vinifera | O | OMT | flavonoid | quercetin, resveratrol, caffeic acid, epicatechin, 3-isobutyl-2-methoxypyrazine, 3-isopropyl-2-methoxypyrazine |
GQ357167 (1) GQ357168 (2) |
ADJ66850 (1) ADJ66851 (2) |
[31] | |
| EnFOMT | Eucalyptus nitida | O | OMT | flavonoid | pinocembrin, chrysin, naringenin, apigenin, alpinetin, 7-hydroxyflavone, hesperetin, luteolin, quercetin | OM96491 | UOO01100 | [83] | |
| GmSOMT-2 | Glycine max | O | OMT | flavonoid | naringenin, daidzein, quercetin, genistein, apigenin | TC178411 (TIGR) | [84] | ||
| VvAOMT2 | Vitis vinifera | O | Cation-dependent OMT | anthocyanin | delphinidin 3-O-glucoside, cyanidin 3-O-glucoside | HQ702997 | ADY18303 | [85] | |
| VvCCoAOMT | Vitis vinifera | O | Cation-dependent OMT | anthocyanin | cyanidin 3-O-glucoside chloride, caffeoyl-CoA | Z54233 | CAA90969 | [86,87,88] | |
| GeD7OMT | Glycyrrhiza echinata | O | OMT | isoflavone | daidzein | AB091685 | BAC58012 | [89] | |
| GeHI4ʹOMT | Glycyrrhiza echinata | O | OMT | isoflavone | (2R,3S)-2,7,4ʹ-trihydroxyisoflavanone, medicarpin | AB091684 | BAC58011 | [89] | |
| GmIOMT1 | Glycine max | O | OMT | isoflavone | 6-hydroxydaidzein, 8-hydroxydaidzein, 3ʹ-hydroxydaidzein | NM_001250549 | NP_001237478 | [90] | |
| MsIOMT | Medicago sativa | O | OMT | isoflavone | 6,7,4ʹ-trihydroxyisoflavone, daidzein, genistein, (+)6a-hydroxymaackiain, (+)maackiain | AF000976 | AAC49927 | 1FP2 | [91,92] |
| MsI7OMT | Medicago truncutula | O | OMT | isoflavone | 6,7,4ʹ-trihydroxyisoflavone, daidzein, (+)6a-hydroxymaackiain | 6CIG | [92] | ||
| MtHI4ʹOMT | Medicago truncutula | O | OMT | isoflavone | (2S, 3R)-2,7,4ʹ-trihydroxyisoflavanone, 6a-hydroxymaackiain | AY942158 | AAY18581 | 1ZG3 1ZHF |
[8] |
| PmIOMT9 | Pueraria montana var. lobata | O | OMT | isoflavone | genistein, daidzen, prunetin, isoformononetin | KP057892 | AKW47171 | [93] | |
| PIOMT4 | Pueraria lobata | O | OMT | isoflavone | 3ʹ-hydroxy-daidzein, luteolin, quercetin | KP057887 | AKW47166 | [94] | |
| McPFOMT | Mesembryanthemum crystallinum | O | Cation-dependent OMT | phenylpropanoid | quarcetagetin, quercetin, caffeoyl coA, caffeic acid | AY145521 | AAN61072 | 3C3Y | [95] |
| GmSOMT-9 | Glycine max | O | Cation-dependent OMT | phenylpropanoid | quercetin, luteolin, taxifolin, catechin, taxifolin, caffeic acid | NM_001249311 | NP_001236240 | [96] | |
| MsCOMT | Medicago sativa | O | OMT | phenylpropanoid | 5-hydroxyconiferaldehyde, caffeic acid, 5-hydroxyferulic acid, caffeoyl aldehyde, caffeoyl alcohol, 5-hydroxyconiferyl alcohol | M63853 | AAB46623 | 1KYW 1KYZ |
[97] |
| ObCVOMT1 | Ocimum basilicum | O | OMT | phenylpropanoid | chavicol, eugenol, t-ioseugenol, t-anol, catechol, phenol, coniferyl alcohol | AF435007 | AAL30423 | [98] | |
| ObEOMT1 | O. basilicum | O | OMT | phenylpropanoid | eugenol, chavicol, t-ioseugenol, guaiacol, caffeic acid, coniferyl alcohol, ferulic acid | AF435008 | AAL30424 | [98] | |
| OsROMT9 | Oryza sativa | O | OMT | phenylpropanoid | quercetin, catechin, eriodictyol, luteolin, myricetin, taxifolin, rhamnetin, caffeic acid | DQ288259 | ABB90678 | [99] | |
| OsOMT1 | Oryza sativa | O | OMT | phenylpropanoid | tricetin, luteolin, quercetin, eriodictyol, 5-hydroxyferulic acid | DQ530257 | ABF72191 | [100] | |
| VpOMT4 | Vanilla planifolia | O | Cation-dependent OMT | phenylpropanoid | caffeoyl coA | JF344740 | ADZ76153 | [101] | |
| RsOMT1,3 | Rauvolfia serpentina | O | Cation-dependent OMT | phenylpropanoid | caffeic acid, 3,5-dimethoxy-4-hydroxycinnamic, 3,4,5-trihydroxybenzoic |
KX687823 (1) KX687825 (3) |
AOZ21151 (1) AOZ21153 (3) |
[102] | |
| MsCCoAOMT | Medicago sativa | O | Cation-dependent OMT | phenylpropanoid | caffeoyl CoA | U20736 | AAC28973 | 1SUI | [103] |
| SbCCoAOMT | Sorghum bicolor | O | Cation-dependent OMT | phenylpropanoid | caffeoyl-CoA | XM_002436505 | XP_002436550 | 5KVA | [104] |
| SbCOMT | Sorghum bicolor | O | OMT | phenylpropanoid | 5-hydroxyconiferaldehyde, caffeic acid, p-coumaraldehyde, coniferaldehyde | XM_002436506 | ADW65743 | [105] | |
| VvOMT3 | Vitis vinifera | O | OMT | phenylpropanoid | 3-isopropyl-2-hydoxypyrazine, 3-isobutyl-2-hydroxypryazine, quercetin, resveratrol, caffeic acid, epicatechin, catechin, eugenol, isoeugenol, orcinol | XM_002436507 | AGK93042 | [32] | |
| ObCCMT1-3 | Ocimum basilicum | O | SABATH | phenylpropanoid | trans-cinnamic acid, hydrocinnamic acid, p-coumaric, 4-hydroxyhydrocinnamic acid, m-courmaric acid, benzoic acid | XM_002436509 |
ABV91100 (1) ABV91101 (2) ABV91102 (3) |
[106] | |
| LpCaOMT | Lolium perenne | O | Cation-dependent OMT | phenylpropanoid | caffeoyl alcohol, caffeic acid, 5-hydroxyferulic acid, caffeoyl aldehyde, 5-hydroxyconiferaldehyde | AF033538 | AAD10253 | 3P9C 3P9I 3P9K |
[107] |
| MOMT4 | Clarkia breweri | O | OMT | phenylpropanoid | coniferyl alcohol, sinapyl alcohol | JX287369 | AFQ94040 | 3TKY | [108] |
| HlOMT1-2 | Humulus lupulus | O | OMT | chalcone | desmethylxanthohumol, xanthohumol |
EU309725 (1) EU309726 (2) |
ABZ89565 (1) ABZ89566 (2) |
[109] | |
| MtChOMT | Medicago truncutula | O | OMT | chalcone | 2′,4,4′-trihydroxychalcone | L10211 | AAB48059 | 1FPQ | [92,110] |
| AcOMT1 | Acorus calamus | O | OMT | polyphenol | isorhapontigenin, resveratrol, piceatannol, oxyresveratrol, pinostilbene, naringenin, anol, isoeugenol, chavicol, eugenol, p-coumaric acid, caffeic acid | LC387636 | BBE32341 | [111] | |
| VvROMT | Vitis vinifera | O | OMT | polyphenol | resveratrol monomethyl ether, resveratrol | FM178870 | CAQ76879 | [112] | |
| AtSAMT | Arabidopsis thaliana, Arabidopsis lyrata | O | SABATH | phenolics | benzoic acid, salicylic acid, anthranilic acid |
AY224595 AY224596 |
AAP57210 AAP57211 |
[113] | |
| CbSAMT | Clarkia breweri | O | SABATH | phenolics | salicylic acid, benzoic acid | AF133053 | AAF00108 | 1M6E | [5,23] |
| MONOTERPENES | |||||||||
| CrLAMT | Catharanthus roseus | O | SABATH | monoterpene iridoid | loganic acid, secologanic acid | EU057974 | ABW38009 | 6C8R | [24] |
| OpLAMT | Ophiorrhiza pumila | O | SABATH | monoterpene iridoid | loganic acid, secologanic acid | MT942677 | QWX38535 | [114] | |
| FURANOCOUMARIN | |||||||||
| PpBMT | Peucedanum praeruptorum | O | OMT | furanocoumarin | bergaptol | KU359196 | ANA75355 | 5XG6 5XOH |
[115] |
| TOCOPHEROLS | |||||||||
| AtγTMT | Arabidopsis thaliana | C | CMT | vitamin E | δ-tocopherol, γ-tocopherol | AF104220 | AAD02882 | [116,117] | |
| Pfγ-TMT | Perilla frutescens | C | CMT | vitamin E | γ-tocopherol | AF213481 | AAL36933 | [118] | |
| POLYKETIDE | |||||||||
| MdOMT | Malus domestica | O | OMT | polyketide | 3,5-dihydroxybiphenyl | MF740747 | ASV64939 | [119] | |
| STEROLS | |||||||||
| GmSMT | Glycine max | C | CMT | sterol | sterol | U43683 | AAB04057 | [120] | |
| TwSMT1 | Tripterygium wilfodii | C | CMT | sterol | sterol | KU885950 | ARI48333 | [121] | |
| Ntsmt2-1 | Nicotiana tabacum | C | CMT | sterol | 24-methylene lophenol |
U71108 U81312 |
AAB62808 AAC34951 |
[122,123] | |
| Ntsmt1-1 | Nicotiana tabacum | C | CMT | sterol | cycloartenol | AF053766 | AAC35787 | [123] | |
| HALIDE/THIOCYANATE | |||||||||
| AtHOL1 | Arabidopsis thaliana | SCN, halides | HTMT | thiocyanate/halide | SCN- > I > Br > Cl (Not F) | AY044314 | AAK73255 | 3LCC | [22,124] |
| RsHTMT | Raphanus sativus | Halides | HTMT | thiocyanate/halide | halides (except F) | AB477013 | BAH84870 | [125] | |
| AMINOBENZOATE | |||||||||
| RgANMT | Ruta graveolens | N | NMT | aminobenzoate | anthranilate | DQ884932 | ABI93949 | [126] | |
| OTHER SMALL MOLECULES | |||||||||
| AtASMT | Arabidopsis thaliana | O | OMT | indole | N-acetylserotonin, serotonin | AT4G35160 | Q9T003 | [127] | |
| EsPaNMT | Ephedra sinica | N | NMT | monoamine alkaloid | (+/-)-cathinone, (+/-)-norephedrine, (-)-norpseudoephedrine, (+/-)-ephedrine, (+)-pseudoephedrine | MH029305 | AWJ64115 | [128] | |
| HvNMT | Hordeum vulgare | N | NMT | indole | 3-aminomethylindole, 3-aminomethylindole, N-methyl-3-aminomethylindole | U54767 | AAC18643 | [129] | |
| SoPEAMT | Spinacia oleracea | N | NMT | phospholipid | phosphatidylethanolamine | AF237633 | AAF61950 | [130] | |
| DTCMT | Brassica rapa | S | SMT | organosulfur | dithiocarbamate | Brara.B01660 Brara.G00303 (Phytozome) |
Brara.B01660 Brara.G00303 (Phytozome) |
[131] | |
| AtJMT | Arabidopsis thaliana | O | SABATH | carboxylic acid | (±) jasmonic acid, dihydrojasmonic acid | AY008434 | AAG23343 | [7] | |
| CrSMT1 | Catharanthus roseus | S | SMT | organosulfur | benzene thiol, furfuryl thiol, 3-mercaptohexyl-acetate, 3-mercaptohexan-1-ol, benzoyl thiol, 1-mercaptopropan-2-ol, pyridine-2-thiol, phenol, 1,3-hexandiol, 1,4-dithiothreitol, 3-mercaptopropan-1-ol, 6-mercapto-hexan-1-ol, 2-mercaptoethanol (BME) | DQ084384 | AAZ32409 | [132] | |
| EjMBMT | Eriobotyra japonica | O | SABATH | carboxylic acid | p-methoxybenzoic acid, benzoic acid, jasmonic acid | LC127197 | BAV54103 | [133] | |
| AtIAMT | Arabidopsis thaliana | O | SABATH | indole | indole acetic acid | NM_124907 | NP_200336 | 3B5I | [134] |
| BoSMT | Brassica oleracea | Se | SeMT | amino acid | DL-selenocysteine, L-selenocysteine, DL-cysteine, L-cysteine, DL-homocysteine | AY817737 | AAX20123 | [135] | |