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. 2022 Dec 23;13:1019582. doi: 10.3389/fimmu.2022.1019582

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Copyright © 2022 Mei, Mi, Qian, Xiao, Yuan and Ding

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Proposed relationship between tumor features, molecular profiles, clinicopathological characteristics, and immunological features of colorectal cancer according to MSI subtype. CIMP, CpG island methylator phenotype; CIN, chromosomal instability; dMMR, mismatch repair deficient; ECM, extracellular matrix; EMT, epithelial–mesenchymal transition; JAK/STAT, Janus kinase/signal transducer and activator of transcription; MSI, microsatellite instability; MSS, microsatellite stable; pMMR, MMR proficient; TGF, transforming growth factor; TIL, tumor-infiltrating lymphocyte; TMB, tumor mutational burden; Tregs, T-regulatory cells; VEGF, vascular endothelial growth factor.