Table 2.
Frequency of common mutations in MSI-H and MSS CRCs.
| Genetic alteration | Mutation Frequency, % | Reference | |
|---|---|---|---|
| MSI-H CRC | MSS CRC | ||
| TP53 loss | 31.6 | 46.4 | (63) |
| KRAS mutations | 36.8 | 2.3 | (63) |
| BRAF-V600E mutation | 36.8 | 1.0 | (63) |
| Cytokeratin 7 loss | 94 a | 61 a | (64) |
| Cytokeratin 20 loss | 30 a | 7 a | (64) |
| CTNNB1 mutations | 10 | 0.7 | (65) |
| HNF1A mutations | 32 | 0.2 | (65) |
| BRCA1 mutations | 19 | 5 | (65) |
| BRCA2 mutations | 50 | 14 | (65) |
| Thymidylate synthase upregulation | 85 | 31 | (65) |
| PTEN upregulation | 71 | 48 | (65) |
| HER2 mutations | 5.6 | 3.7 | (66) |
a
Tumors harbored BRAF mutations.