Table 1.
Baseline demographics and characteristics.
| Overall regdanvimab n = 418 |
Overall SoC n = 304 |
Delta variant subgroup regdanvimab n = 297 |
Delta variant subgroup SoC n = 115 |
|
|---|---|---|---|---|
| Age, years | ||||
| Median (range) | 52 (18, 90) | 60 (18, 91) | 46 (18, 88) | 42 (18, 82) |
| Male, n (%) | 198 (47.4) | 147 (48.4) | 148 (49.8) | 68 (59.1) |
| Female, n (%) | 220 (52.6) | 157 (51.6) | 149 (50.2) | 47 (40.9) |
| BMI, mean (SD), kg/m2 | 25.0 (4.3) | 24.8 (3.6) | 25.2 (4.4) | 24.4 (3.9) |
| At least one high-risk factor | 288 (68.9) | 236 (77.6) | 177 (59.6) | 57 (49.6) |
| Age >50 years | 221 (52.9) | 198 (65.1) | 121 (40.7) | 34 (29.6) |
| BMI >30 kg/m² | 46 (11.0) | 25 (8.2) | 39 (13.1) | 11 (9.6) |
| Cardiovascular disease, including hypertension | 145 (34.7) | 105 (34.5) | 77 (25.9) | 23 (20.0) |
| Chronic lung disease, including asthma | 25 (6.0) | 15 (4.9) | 18 (6.1) | 4 (3.5) |
| Type 1 or type 2 diabetes mellitus | 63 (15.1) | 66 (21.7) | 35 (11.8) | 8 (7.0) |
| Chronic kidney disease, including dialysis | 2 (0.5) | 4 (1.3) | 2 (0.7) | 1 (0.9) |
| Chronic liver disease | 7 (1.7) | 10 (3.3) | 5 (1.7) | 4 (3.5) |
| Immunosuppressed status | 9 (2.2)a | 4 (1.3)b | 5 (1.7) | 0 |
| Baseline COVID-19 symptoms, n (%) | ||||
| Fever | 208 (49.8) | 125 (41.1) | 151 (50.8) | 40 (34.8) |
| Shortness of breath | 32 (7.7) | 12 (3.9) | 28 (9.4) | 8 (7.0) |
| Cough | 227 (54.3) | 158 (52.0) | 168 (56.6) | 75 (65.2) |
| Diarrhea | 24 (5.7) | 13 (4.3) | 18 (6.1) | 7 (6.1) |
| Sputum | 108 (25.8) | 62 (20.4) | 83 (27.9) | 32 (27.8) |
| Sore throat | 104 (24.9) | 55 (18.1) | 67 (22.6) | 23 (20.0) |
| Headache | 122 (29.2) | 72 (23.7) | 90 (30.3) | 35 (30.4) |
| Myalgia | 92 (22.0) | 62 (20.4) | 60 (20.2) | 15 (13.0) |
| Lack of taste or smell | 38 (9.1) | 22 (7.2) | 33 (11.1) | 11 (9.6) |
| Disease severity, n (%) | ||||
| Mild | 20 (4.8) | 53 (17.4) | 5 (1.7) | 5 (4.3) |
| Moderate | 398 (95.2) | 251 (82.6) | 292 (98.3) | 110 (95.7) |
| Time since symptom onsetc, median (range), days | 2.0 (−2.0, 7.0) | 3.0 (0.0, 26.0) | 3.0 (−1.0, 7.0) | 7.0 (0.0, 26.0) |
| Baseline peripheral oxygen saturation level in room air, median (range), % | 97 (94, 100) | 98 (94, 100) | 97 (94, 100) | 97 (94, 99) |
| Unvaccinated, n (%) | 297 (71.1) | 275 (90.5) | 177 (59.6) | 86 (74.8) |
a
Neoplasm, malignant (n = 6), systemic lupus erythematosus (n = 2) and acquired immunodeficiency syndrome (n = 1)
b
Neoplasm, malignant (n = 2), rheumatoid arthritis (n = 1) and psoriasis (n = 1)
c
Date of admission (day 1) - date of earliest symptom start.
BMI, body mass index; SoC, standard of care.