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. 2022 Dec 30;2022:5774641. doi: 10.1155/2022/5774641

Figure 4.

Figure 4

The role of OGG1 in the regulation of autophagy. DNA single- or double-strand oxidative damage recruits OGG1 excision repair 8-oxoG. OGG1 interacts with PARP1 and induces ATP depletion and the activation of AMPK. AMPK promotes TAK1/JNK pathway and ULK1 to regulate autophagy process. Additionally, OGG1 binds to the promoter region of ATG7 to induce autophagy. AMPK and TSC2 activation may negatively affect the expression of OGG1. On the other hand, OGG1 is found to inhibit autophagy by activating the PI3K/AKT/mTOR pathway in specific damage models. ATP: adenosine triphosphate; AMPK: adenosine monophosphate-activated protein kinase; TAK1: transforming growth factor β-activated kinase 1; JNK: c-jun N-terminal kinase; ULK1: Unc-51-like autophagy-activating kinase 1; TSC2: tuberous sclerosis complex 2.