Table 4.
Prevalent and new neurological events in participants with cSS
| Case | Cohort | Location of cSS | Neurological preceding MRI | Subsequent neurological events | Follow-up (years) since MRI | Topographic correlation between cSS and new events |
|---|---|---|---|---|---|---|
| 1 | FHS | Left occipital | None | Left occipital ICH | 5.8 | Yes |
| 2 | FHS | Bifrontal | Remote SAH in 1980 TIA 1996-speech disturbance and L face weakness | AD/Dementia | 5.6 | uncertain |
| 3 | FHS | Left parietal | Episode non-focal weakness | Death from left parietal ICH | 2.3 | Yes |
| 4 | FHS | Right frontal | No | subsequent seizures (episodes of non-focal unresponsiveness and amnesia of events) | 6 | uncertain |
| 5 | FHS | Left parietal | No | No | 8.6 | – |
| 6 | FHS | Left frontal | Episode of paresthesias | No | 3.7 | – |
| 7 | FHS | Cerebellum, brainstem, and frontal | Episodes of diplopia | Episodes of vertical diplopia | 1 | Yes |
| 8 | FHS | Left frontal | No | Vascular death due to stroke of unspecified type (focal deficits noted preceding death, but no imaging or autopsy available) | 3.8 | uncertain |
| 9 | RS | Right parietal; right occipital | None | ICH right hemisphere. Dementia | 3 | Yes |
| 10 | RS | Right occipital | 1999 TIA | None | 2 | – |
| 11 | RS | Right frontal | Amaurosis fugax | Unspecified stroke left hemisphere. Dementia | 6 | No |
| 12 | RS | Right frontal | Collapse. Ischemic stroke right hemisphere | Stroke unspecified left hemisphere | 5.5 | Yes |
| 13 | RS | Right parietal and left occipital | None | ICH left hemisphere | 7.5 | Yes |
| 14 | RS | Left parietal and right parietal/occipital | None | Ischemic stroke right hemisphere | 7 | Yes |
| 15 | RS | Left parietal | None | None | 5 | – |
| 16 | RS | Left parietal | ICH Left parietal | None | 9 | – |
| 17 | RS | Left frontal/parietal/occipital and right frontal/occipital | None | None | 8 | |
| 18 | RS | Left frontal/temporal/parietal/occipital and right frontal/parietal | ICH left occipital | Dizziness | 9.5 | No |
| 19 | RS | Left frontal/occipitaloccipital and right frontal | Perceptive hearing loss Seizure | Unspecified stroke right hemisphere | 1 | Yes |
| 20 | RS | Bioccipital | Dizziness | ICH left hemisphere | 3.5 | Yes |
| 21 | RS | Bioccipital | None | Primary CNS lymphoma | 6 | uncertain |
| 22 | RS | Left occipital | None | MCI | 9 | No |
| 23 | RS | Left occipital | None | Hearing loss. Balance disturbance TIA left hemisphere. Ischemic stroke left hemisphere | 5 | Yes |
| 24 | RS | Left frontal and right occipital | None | None | 5 | – |
| 25 | RS | Left frontal | None | None | 10 | – |
| 26 | RS | Right frontal/parietal | None | TIA vertebrobasilar | 7 | No |
cSS: cortical superficial siderosis; FHS: Framingham Heart Study; ICH: intracerebral hemorrhage; MCI: mild cognitive impairment; RS: Rotterdam Study; SAH: subarachnoid hemorrhage; TIA: transient ischemic attack.