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. 2022 Nov 30;122(1):43–53. doi: 10.1016/j.bpj.2022.11.2943

Figure 3.

Figure 3

Cellular response to matrix viscosity and viscoelasticity. (A) Descriptions of the viscous matrix molecular clutch model. (B) Relationships between FAKpY397 or YAP/TAZ N/C ratio and viscosity followed a Hill-type function. (C) A linear relationship between FAK activation in adhesions and matrix stiffness in response to matrix viscosity was observed. (D) Schematic depicting the molecular clutch model for a viscoelastic matrix. (E) At low long-term stiffness, intermediate viscosity promotes an increased YAP/TAZ N/C ratio, but low viscosity inhibits this. (F) The bond average forces increased with the ratio of long-term stiffness to short-term stiffness. The integrin number increased with the ratio of long-term stiffness to short-term stiffness at a small relaxation time and decreased with the ratio of long-term stiffness to short-term stiffness at intermediate relaxation times. Mean ± SE of n = 10 independent simulations for each condition. To see this figure in color, go online.