Figure 5.
YAP/TAZ response to stress-dependent matrix viscoplasticity. (A) The molecular clutch model for a stress-dependent viscoplastic matrix. (B) Traction force increased with the ratio of long-term to short-term stiffness Klong/Kshort for an SLS element and Bingham element but decreased with the ratio of long-term to short-term stiffness Klong/Kshort for a Norton-Hoff element. (C) For stress-dependent viscoplasticity, the YAP/TAZ N/C ratio showed different relationships with threshold force depending upon different short-term stiffnesses. (D) The YAP/TAZ N/C ratio increased with short-term stiffness. All simulation results are the average value of 100 simulated trajectories. To see this figure in color, go online.