Table 2.
Clinical characteristics by Chicago Classification v4.0 (CCv4.0) Impression of EGJ outflow obstruction (EGJOO) based on complementary application of high resolution manometry (HRM) and FLIP Panometry.
| HRM+FLIP Panometry CCv4.0 Impression | Normal EGJ opening | ‘Conclusive EGJOO’ | Inconclusive |
|---|---|---|---|
|
| |||
| Patient characteristics | |||
|
| |||
| n (%) | 30 (22) | 68 (49) | 41 (29) |
|
| |||
| Age, mean (SD) years | 56 (16) | 60 (14) | 60 (14) |
|
| |||
| Sex; n (%) female | 20 (67) | 34 (50) | 25 (61) |
|
| |||
| Baseline HRM | |||
|
| |||
| HRM, median supine IRP, mmHg, median (IQR)* | 22 (18–27) | 26 (22–34) | 22 (18–26) |
|
| |||
| HRM, median upright IRP, mmHg, median (IQR)** | 18 (14–24) | 29 (20–35) | 20 (17–27) |
|
| |||
| HRM, Basal EGJ pressure (end-expiration), mmHg, median (IQR) | 31 (18–39) | 32 (21–46) | 30 (19–36) |
|
| |||
| HRM EGJ morphology, n (%) | |||
| Type I | 20 (67) | 56 (82) | 34 (83) |
| Type II or III | 10 (33) | 12 (18) | 7 (17) |
|
| |||
| Intrabolus pressurization (IBP); Percent of supine swallows with IBP > 20mmHg, median (IQR)* | 80 (50–100) | 100 (70–100) | 100 (50–100) |
|
| |||
| HRM-primary peristalsis/contractility pattern, n (%)* | |||
| Normal | 26 (87) | 31 (46) | 22 (53) |
| Ineffective | 2 (7) | 6 (9) | 0 |
| Hypercontractile | 2 (7) | 11 (16) | 8 (20) |
| Premature | 1 (3) | 20 (29) | 11 (27) |
|
| |||
| HRM-rapid drink challenge (RDC) | |||
| [Completed RDC] | [n=27] | [n=60] | [n=38] |
| RDC-IRP, mmHg, median (IQR)** | 10 (5–13) | 15 (10–24) | 12 (9–16) |
| RDC-IRP > 12mmHg, n (%)* | 8 (29) | 37 (62) | 16 (42) |
| PEP>30mmHg, n (%)** | 7 (26) | 49 (82) | 24 (63) |
|
| |||
| Baseline Timed Barium Esophagram (TBE) | |||
|
| |||
| [Completed TBE] | [n=17] | [n=35] | [n=12] |
| I minute column height, cm, median (IQR) | 0 (0–4) | 13 (7–21) | 0 (0–4) |
| 5 minute column height, cm, median (IQR) | 0 (0–0) | 3 (0–13) | 0 (0–0) |
|
| |||
| Baseline symptom scores | |||
|
| |||
| [completed Eckardt score] | [n=23] | [n=47] | [n=34] |
| Eckardt score, median (IQR) | 4 (2–8) | 5 (3–8) | 5 (2–7) |
| Eckardt score ≥3, n (%) | 16 (70) | 41 (87) | 25 (74) |
| Eckardt dysphagia score, median (IQR) | 0 (0–1) | 1 (0–2) | 1 (0–2) |
| Eckardt dysphagia score ≥2, n (%) | 10 (40) | 32 (68) | 19 (56) |
|
| |||
| [completed BEDQ] | [n=25] | [n=51] | [n=36] |
| BEDQ score, median (IQR)* | 6 (4–17) | 16 (10–23) | 18 (9–23) |
| BEDQ score ≥10 n (%)* | 10 (40) | 40 (78) | 27 (75) |
|
| |||
| [completed GerdQ] | [n=24] | [n=46] | [n=31] |
| GerdQ score, median (IQR) | 9 (6–11) | 9 (8–10) | 7 (6–10) |
| GerdQ score ≥9, n (%) | 14 (58) | 29 (63) | 13 (42) |
*
P<0.05
**
P<0.001 on comparison between EGJOO impressions.
CR – contractile response; BEDQ - Brief Esophageal Dysphagia Questionnaire; IRP – integrated relaxation pressure; PEP – panesophageal pressurization.