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. 2023 Jan 6;13:287. doi: 10.1038/s41598-022-27261-0

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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WNT/β-CATENIN target gene expression is reduced in β-CATENIN-deficient CRC cells. (a–d) Expression of the WNT/β-CATENIN target genes AXIN2, ASCL2, RNF43, MYC, and TERT was analyzed by qRT-PCR in HT29 (a), HCT116 (b), SW480 (c) and RKO (d) cell clones with biallelic WT and mutant CTNNB1 genes. Transcript levels were normalized to GAPDH, and are displayed as relative expression (rel. expr.). The box plots display aggregated expression data from CTNNB1^+/+ and CTNNB1^−/− cell clones. Each dot represents a separate measurement with dot color identifying individual clones. For statistical analysis, LMM was performed (n = 3). nd not detectable, ns not significant.