Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Jan 6;13:287. doi: 10.1038/s41598-022-27261-0

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Gene expression changes in β-CATENIN-deficient CRC cell lines affect cell-type-specific and cell-type-overarching biological processes. (a–c) Gene set enrichment analysis of gene sets was performed on the CTNNB1-dependent DEGs in HT29 (a), HCT116 (b) and SW480 cells (c) using Fisher’s exact test. The normalized enrichment scores (NES) and the corresponding adj. p-values for the top 20 positively- and negatively enriched Gene Ontology (GO) terms “Biological process” are shown in the bar plot. (d,e) Comparison of gene expression changes following inactivation of TCF7L2 and CTNNB1 in HT29 (d) and HCT116 cells (e). The Venn diagrams show the numbers of DEGs specific and common to cells with biallelic WT and mutant TCF7L2 or CTNNB1 genes. (d,e) As thresholds to call DEGs, absolute values of a log₂(fold change) > 1 and an adjusted p-value < 0.05 were used.