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. 2023 Jan 6;6:13. doi: 10.1038/s42003-022-04408-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Venn diagram demonstrates the numbers of the downregulated genes and the upregulated genes analyzed in Fig. 2. There were 131 downregulated genes and 127 upregulated genes for an IPA. b A graphical summary shows the senescence cells, which are induced by p53 and CDKN1A, connected by the network analysis to the cellular functions.