Table 1.
Group HI injury outcomes.
| 2H (n = 5) | 4H (n = 5) | 8H (n = 4) | 12H (n = 4) | 24H (n = 5) | F value | P value | |
|---|---|---|---|---|---|---|---|
| Total hypoxia duration (mins) | 30.5 ± 3.0 | 31.85 ± 5.4 | 29.8 ± 4.6 | 30.8 ± 3.6 | 31.8 ± 2.4 | 0.21 | 0.92 |
| MABP pre insult (mmHg) | 44 ± 7 | 40 ± 6 | 39 ± 5 | 40 ± 11 | 40 ± 3 | 0.34 | 0.84 |
| MABP max (mmHg) | 62 ± 10 | 59 ± 9 | 62 ± 14 | 64 ± 22 | 62 ± 15 | 0.08 | 0.98 |
| MABP end insult (mmHg) | 17 ± 5 | 14 ± 4 | 19 ± 5 | 17 ± 7 | 15 ± 3 | 0.65 | 0.62 |
| Total ischemic period (mins) | 11.7 ± 5.9 | 15.5 ± 7.03 | 12.6 ± 9.7 | 14.6 ± 11.2 | 16.9 ± 7.37 | 0.32 | 0.85 |
| Time bradycardic (mins) | 2.0 ± 2.2 | 2.2 ± 2.6 | 4.1 ± 4.8 | 4.7 ± 4.9 | 1.42 ± 1.25 | 0.84 | 0.51 |
| pH before insult | 7.466 ± 0.066 | 7.446 ± 0.101 | 7.461 ± 0.034 | 7.439 ± 0.049 | 7.419 ± 0.022 | 0.42 | 0.78 |
| pH end insult | 7.105 ± 0.149 | 7.111 ± 0.047 | 7.044 ± 0.061 | 7.041 ± 0.028 | 7.081 ± 0.059 | 0.69 | 0.60 |
| HCO3- pre insult (mmol/L) | 29.6 ± 4.2 | 28.2 ± 6.5 | 28.0 ± 0.2 | 25.4 ± 2.4 | 26.7 ± 1.1 | 0.65 | 0.65 |
| HCO3− end insult (mmol/L) | 12.9 ± 5.0 | 13.6 ± 2.8 | 11.6 ± 2.2 | 10.6 ± 2.7 | 10.6 ± 1.1 | 0.93 | 0.46 |
| ABE before insult (mmol/L) | 5.5 ± 4.5 | 3.9 ± 7.0 | 4.2 ± 0.3 | 1.1 ± 1.3 | 2.1 ± 1.1 | 0.83 | 0.51 |
| ABE end insult (mmol/L) | − 13.7 ± 7.5 | − 14.4 ± 3.4 | − 15.7 ± 3.3 | − 17.3 ± 4.3 | − 17.0 ± 1.7 | 0.55 | 0.70 |
| pCO2 before insult (mmHg) | 38.9 ± 3.6 | 40.6 ± 2.9 | 39.9 ± 4.1 | 37.2 ± 2.2 | 41.4 ± 3.3 | 1.12 | 0.37 |
| pCO2 end insult (mmHg) | 46.9 ± 8.4 | 46.8 ± 9.8 | 54.9 ± 6.3 | 47.8 ± 13.7 | 41.2 ± 4.2 | 1.33 | 0.29 |
| pO2 pre insult (mmHg) | 99.6 ± 20.8 | 104.7 ± 29.2 | 131.8 ± 2.6 | 100.7 ± 15.0 | 94.6 ± 3.7 | 2.78 | 0.06 |
| pO2 end insult (mmHg) | 14.1 ± 2.6 | 21.9 ± 8.4 | 24.1 ± 7.2 | 19.4 ± 9.3 | 20.0 ± 5.0 | 1.08 | 0.39 |
| Glucose pre insult (mmol/L) | 6.7 ± 2.1 | 5.9 ± 1.4 | 7.5 ± 2.2 | 5.3 ± 1.6 | 5.6 ± 1.0 | 1.40 | 0.27 |
| Glucose end insult (mmol/L) | 8.2 ± 2.0 | 5.3 ± 2.4 | 8.6 ± 2.0 | 7.4 ± 2.9 | 7.2 ± 1.3 | 1.56 | 0.23 |
| Lactate pre insult (mmol/L) | 1.2 ± 0.5 | 1.7 ± 0.3 | 1.9 ± 0.4 | 2.3 ± 0.3 | 1.7 ± 0.7 | 1.43 | 0.26 |
| Lactate end insult (mmol/L) | 8.1 ± 6.0 | 9.7 ± 4.5 | 5.2 ± 1.6 | 5.2 ± 1.8 | 7.4 ± 2.9 | 0.74 | 0.58 |
No significant differences were observed between groups at pre or post insult times. Statistical comparisons refer to results of ordinary one-way ANOVA. Statistical significance was accepted at p < 0.05.
ABE arterial base excess; (number)H group culled hours post injury; MABP Mean arterial blood pressure; mmHg millimetres of mercury; mmol/L millimoles per liter; pCO2 partial pressure of carbon dioxide; pO2 partial pressure of oxygen.