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. 2022 Nov 16;197(2):287–297. doi: 10.1007/s10549-022-06787-x

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — CD20 positive cells and TLS between four immune subtypes based on CD8 and PD-L1. Violin plots of CD 20 positive cells (a) in patients with low CD8/PD-L1(−) (blue), high CD8/PD-L1(−) (red), low CD8/PD-L1( +) (green), and high CD8/PD-L1( +) (purple). The bars represent the first, median, and third quartile values. *p < 0.05, ****p < 0.0001. b Association between TLS amount and immune subtypes. Abbreviations: PD-L1, programmed cell death-ligand 1; TLS, tertiary lymphoid structure