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. 2023 Jan 3;36:100870. doi: 10.1016/j.neo.2022.100870

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© 2022 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig 1 — Intracranial dosing procedure. ∼45 min after a topical anesthetic agent is applied, (A) the Ommaya or shunt reservoir site is sterilized with betadine, (B) a 25-guage butterfly needle is inserted, and 0.5 mL preservative-free normal saline (PFNS) is infused. The sterile syringe of PFNS is removed and (C) a new 10 mL syringe is connected to withdraw CSF for clinical and correlative studies. That syringe is removed, and (D) a syringe with CAR T cells is connected. Finally, that syringe is removed and a syringe with 2.5 mL PFNS is connected and infused, after which the needle, with the syringe connected, is removed.