Figure 9.

Evaluation of wound healing

(A) Schematic diagram of the application of different scaffolds in rat wounds.

(B) Schematic diagram of autologous skin transplantation combined with drug-loaded scaffold transplantation in rats.

(C) Representative images of survival at each time point after full-thickness skin graft injury. The edges of the unhealed wound are encircled by a red dotted line.

(D) Overview of neovascularization on days 14 and 21 after different treatments.

(E) H&E staining of graft sections collected at different time points from varying hair follicles (black star) and implants (black arrow).

(F) Masson’s trichromatic staining of skin grafts and blood vessels (red arrow).

(G) Changes of unhealed wounds on days 3, 7, and 14 after injury.

(H) Quantitative vascular analysis.

(I) Quantitative analysis of collagen staining strength in histological sections (∗p < 0.05, ∗∗∗p < 0.001).