FIGURE 3.

Histopathological findings for a patient with mixed Lewy body dementia and Alzheimer disease neuropathology^a

^aMicroscopic views of the midbrain substantia nigra with hematoxylin and eosin (panel A) and synuclein immunohistochemistry (panel B) demonstrate Lewy bodies (arrows) and extraneuronal pigment (arrow-head). Tau immunohistochemistry on Ammon’s horn of the hippocampus indicates the presence of neurofibrillary tangles (panel C). β-amyloid immunohistochemistry of the frontal cortex indicates the presence of β-amyloid plaques (arrow) and cerebral amyloid angiopathy (arrowhead) (panel D).