Figure 5.

Exercise inhibited adipsin-mediated complement pathway activation on osteoclasts. Adipsin plays an essential role in C3 convertase forming and activation of the subsequent alternative complement pathway. As the central component of the complement pathway, C3 and the complement pathway are important in osteoclast differentiation. Exercise inhibits the adipokine adipsin expression and affects osteoclasts through its mediated complement system. In addition, exercise can restrain BMSC adipogenic differentiation to protect bone health. IS, insulin sensitivity; BW, body weight.