Table 2.
Hazard ratio (95% confidence interval) for osteoporosis in the gout and control groups with subgroup analyses according to age and sex.
| Characteristics | No. of Osteoporosis/ No. of Participants |
Follow-Up Duration, Person-Years |
Incidence Rate, Per 1000 Person-Years |
Hazard Ratios for Osteoporosis | |||
|---|---|---|---|---|---|---|---|
| Crude † | p-Value | Adjusted ‡ | p-Value | ||||
| Total participants (n = 81,525) | |||||||
| Gout | 761/16,305 | 94,898 | 8.0 | 1.10 (1.01–1.19) | 0.022 | 1.11 (1.02–1.20) | 0.011 * |
| Control | 2805/65,220 | 382,132 | 7.3 | 1 | 1 | ||
| Age < 60 years old (n = 44,945) | |||||||
| Gout | 255/8989 | 60,212 | 4.2 | 1.21 (1.05–1.39) | 0.009 * | 1.22 (1.06–1.41) | 0.005 * |
| Control | 859/35,956 | 242,560 | 3.5 | 1 | 1 | ||
| Age ≥ 60 years old (n = 36,580) | |||||||
| Gout | 506/7316 | 34,686 | 14.6 | 1.05 (0.95–1.16) | 0.324 | 1.06 (0.96–1.17) | 0.250 |
| Control | 1946/29,264 | 139,572 | 13.9 | 1 | 1 | ||
| Males (n = 69,705) | |||||||
| Gout | 344/13,941 | 82,815 | 4.2 | 1.08 (0.96–1.22) | 0.189 | 1.13 (1.00–1.28) | 0.043 |
| Control | 1270/55,764 | 332,450 | 3.8 | 1 | 1 | ||
| Females (n = 11,820) | |||||||
| Gout | 417/2364 | 12,083 | 34.5 | 1.11 (1.00–1.24) | 0.058 | 1.11 (1.00–1.24) | 0.055 |
| Control | 1535/9456 | 49,682 | 30.9 | 1 | 1 | ||
* Stratified Cox proportional hazard model, Significance at p < 0.05 with Bonferroni correction. † Models were stratified by age, sex, income, and region of residence. ‡ Adjusted for total cholesterol, systolic blood pressure, diastolic blood pressure, fasting blood glucose, obesity, smoking, alcohol consumption, and Charlson comorbidity index score.