Table 4.
Hazard ratio (95% confidence interval) for hip fracture in the gout and control groups with subgroup analyses according to age and sex.
| Characteristics | No. of Hip Fracture/ No. of Participants |
Follow-Up Duration, Person-Years |
Incidence Rate, Per 1000 Person-Years |
Hazard Ratios for Hip Fracture | |||
|---|---|---|---|---|---|---|---|
| Crude † | p | Adjusted ‡ | p | ||||
| Total participants (n = 81,525) | |||||||
| Gout | 127/16,305 | 98,689 | 1.3 | 1.02 (0.84–1.24) | 0.872 | 1.00 (0.82–1.22) | 0.997 |
| Control | 500/65,220 | 395,473 | 1.3 | 1 | 1 | ||
| Age < 60 years old (n = 44,945) | |||||||
| Gout | 31/8989 | 61,573 | 0.5 | 1.27 (0.85–1.90) | 0.245 | 1.23 (0.81–1.85) | 0.335 |
| Control | 98/35,956 | 247,060 | 0.4 | 1 | 1 | ||
| Age ≥ 60 years old (n = 36,580) | |||||||
| Gout | 96/7316 | 37,116 | 2.6 | 0.95 (0.76–1.19) | 0.679 | 0.94 (0.75–1.18) | 0.604 |
| Control | 402/29,264 | 148,413 | 2.7 | 1 | 1 | ||
| Males (n = 69,705) | |||||||
| Gout | 108/13,941 | 84,172 | 1.3 | 1.05 (0.85–1.30) | 0.641 | 1.09 (0.88–1.35) | 0.445 |
| Control | 410/55,764 | 336,974 | 1.2 | 1 | 1 | ||
| Females (n = 11,820) | |||||||
| Gout | 19/2364 | 14,517 | 1.3 | 0.85 (0.52–1.40) | 0.527 | 0.71 (0.42–1.19) | 0.191 |
| Control | 90/9456 | 58,499 | 1.5 | 1 | 1 | ||
Stratified Cox proportional hazard model, Significance at p < 0.05 with Bonferroni correction. † Models were stratified by age, sex, income, and region of residence. ‡ Adjusted for total cholesterol, systolic blood pressure, diastolic blood pressure, fasting blood glucose, obesity, smoking, alcohol consumption, osteoporosis history and Charlson comorbidity index score.