Table 5.
Hazard ratio (95% confidence interval) for spine fracture in the gout and control groups with subgroup analyses according to age and sex.
| Characteristics | No. of Spine Fracture/ No. of Participants |
Follow-Up Duration, Person-Years |
Incidence Rate, Per 1000 Person-Years |
Hazard Ratios for Spine Fracture | |||
|---|---|---|---|---|---|---|---|
| Crude † | p | Adjusted ‡ | p | ||||
| Total participants (n = 81,525) | |||||||
| Gout | 437/16,305 | 97,555 | 4.5 | 1.00 (0.90–1.12) | 0.943 | 0.98 (0.88–1.09) | 0.642 |
| Control | 1746/65,220 | 390,661 | 4.5 | 1 | 1 | ||
| Age < 60 years old (n = 44,945) | |||||||
| Gout | 132/8989 | 61,194 | 2.2 | 1.11 (0.92–1.35) | 0.287 | 1.06 (0.87–1.29) | 0.562 |
| Control | 479/35,956 | 245,546 | 2.0 | 1 | 1 | ||
| Age ≥ 60 years old (n = 36,580) | |||||||
| Gout | 305/7316 | 36,361 | 8.4 | 0.96 (0.85–1.09) | 0.567 | 0.94 (0.83–1.07) | 0.359 |
| Control | 1267/29,264 | 145,115 | 8.7 | 1 | 1 | ||
| Males (n = 69,705) | |||||||
| Gout | 330/13,941 | 83,344 | 4.0 | 1.02 (0.91–1.16) | 0.711 | 1.03 (0.91–1.16) | 0.679 |
| Control | 1286/55,764 | 333,657 | 3.9 | 1 | 1 | ||
| Females (n = 11,820) | |||||||
| Gout | 107/2364 | 14,211 | 7.5 | 0.95 (0.77–1.17) | 0.627 | 0.86 (0.69–1.06) | 0.160 |
| Control | 460/9456 | 57,004 | 8.1 | 1 | 1 | ||
Stratified Cox proportional hazard model, Significance at p < 0.05 with Bonferroni correction. † Models were stratified by age, sex, income, and region of residence. ‡ Adjusted for total cholesterol, systolic blood pressure, diastolic blood pressure, fasting blood glucose, obesity, smoking, alcohol consumption, osteoporosis history and Charlson comorbidity index score.