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. 2022 Dec 23;13:1039009. doi: 10.3389/fimmu.2022.1039009

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Copyright © 2022 Zhao, Goewey Ruiz, Sebastian and Kidane

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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cGAS/STING activation in dRP lyase deficient mice. (A) Immunohistochemistry staining of stomach tissue section with DSB marker (gH2AX) in dRP lyase deficient (L22P) and WT mice; (B) Percentage of cells positive for gH2AX; (C) Immunohistochemistry staining of STING on stomach tissue of dRP lyase deficient versus proficient WT mice; (D) Percent of cells positive for STING (E) Immunohistochemistry stain of Ph-IRF3 localization in stomach tissue section of L22P versus WT mice (F) Percent of cells positive for ph-IRF3 (G) Quantification of mRNA cytosolic DNA-STING signaling mediated cytokines expression using qRT-PCR from stomach tissues derived from dRP lyase deficient and proficient WT mice. Data were analyzed using student t-test in GraphPad Prism; P*<0.05, P**<0.01, P***<0.001.