Resveratrol-modulated biochemical targets. AP-1, activator protein 1; CAT, catalase; CDK, cyclin dependent kinase; COX, cyclooxygenase; CRP, C-reactive protein; CYP, cytochrome P450; ER, estrogen receptor; ERK, extra cellularly regulated kinase; GPx, glutathione peroxidase; HIF, hypoxia inducing factor; hTERT, human telomerase reverse transcriptase; ICAM, intracellular adhesion molecule; IAP, inhibitor of apoptosis proteins; iNOS, inducible nitric oxide; MAPK, mitogen activated protein kinase; MMP, matrix metalloproteinase; NFκB, nuclear factor kappa B; PI3K, phosphoinositide-3 kinase; Rb, retinoblastoma; SOD, superoxide dismutase; STAT, signal transducer and activator of transcription; SPARC, secreted protein acidic and rich in cysteine; TNF, tumor necrosis factor; VEGF, vascular endothelial growth factor.