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Mastocytosis in colonic tissue in DCA vehicle (Non-IBS), 4 mmol/L DCA (IBS)-, L. fermentum (109 CFU) (L. ferm)-, Gabapentin at 70 mg/kg (GBP)- and Rifaximin at 150 mg/kg (RFX)- treated rats. Representative distal colon tissue stained with toluidine blue (scale bar = 20 μm). Yellow arrows show mast cells inactivated in Non-IBS tissue and mast cells activated in IBS tissue at 100X.
