Table 2.

Characteristics of included studies concerning atrophic vaginitis.

Study	Character of the Study	Number of Participants		Outcomes
		Study Group	Control Group
Ziagham et al. (2012) [37]	The double-blinded randomized controlled trial	20 postmenopausal women received vaginal tablets containing 1 mg vitamin E for 8 weeks—daily for 2 weeks, and subsequently, one suppository three days a week	20 postmenopausal women received vaginal tablets containing 5 mg of hyaluronic acid sodium salt for 8 weeks—daily for 2 weeks, and subsequently, one suppository three days a week	Both interventions provided relief of vaginal symptoms, however vaginal hyaluronic acid group was more effective in reducing the genitourinary symptoms of menopause than vitamin E.
Ziagham et al. (2013) [38]	The double-blinded randomized controlled trial	20 postmenopausal women received vaginal suppositories containing 1 mg of vitamin E for 8 weeks—daily for 2 weeks, and subsequently, one every other day	22 postmenopausal women received placebo suppositories with semisynthetic fatty acid triglyceride (placebo) for 8 weeks—daily for 2 weeks, and subsequently, one every other day	Vaginal vitamin E is more effective in reducing the genitourinary symptoms of menopause than placebo.
Parnan Emamverdikhan et al. (2016) [39]	The interventional, clinical trial	26 postmenopausal women received 100 IU vitamin E vaginal suppositories for 12 weeks—daily for 2 weeks and subsequently twice a week	26 postmenopausal women received 0.625 mgconjugated estrogen in vaginal creamfor 12 weeks daily for 2 weeks and subsequently twice a week	Estrogens are more effective in atrophic vaginitis. Nevertheless, vitamin E improve the laboratory signs of vaginal atrophy.
Golmakani et al. (2018) [40]	The single-blinded randomized controlled trial	26 postmenopausal women received 100 IU vitamin E vaginal suppository for 12 weeks—daily for 2 weeks and subsequently twice a week	26 postmenopausal women received 0.625 mg conjugated estrogen in vaginal cream for 12 weeks—daily for 2 weeks and subsequently twice a week	Vitamin E and estrogens have similar improving potential of sexual function of postmenopausal women.