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. 2022 Dec 21;12(1):25. doi: 10.3390/plants12010025

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Urinary parameters (8 h) after oral treatment with hesperidin (HSP) in combination with hydrochlorothiazide (HCTZ) or amiloride (AMLR). (A,B) Urine Na⁺ excretion after treatment with HSP plus HCTZ. (C,D) Urine K⁺ excretion after treatment with HSP plus HCTZ. (E,F) Urine Na⁺ excretion after treatment with HSP plus AMLR. (G,H) Urine K⁺ excretion after treatment with HSP plus AMLR. The values show the mean ± SEM. Statistical analysis was performed by means of one-way ANOVA followed by Dunnett’s multiple comparisons test. * p < 0.05 when compared with the VEH (vehicle; saline 10 mL/kg); # p < 0.05 when compared with the HSP-only group.