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. 2022 Dec 21;12(1):25. doi: 10.3390/plants12010025

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Urine volume of female and male spontaneously hypertensive rats (SHR) treated with hesperidin (HSP) in the presence of atropine (ATRO) or indomethacin (INDO). (A) Urine volume of female rats after treatment with HSP in the presence of ATRO. (B) Urine volume of male rats after treatment with HSP in the presence of ATRO. (C) Urine volume of female rats after treatment with HSP in the presence of INDO. (D) Urine volume of male rats after treatment with HSP in the presence of INDO. The values show the mean ± SEM. Statistical analysis was performed by means of two-way ANOVA followed by Dunnett’s multiple comparisons test. * p < 0.05 when compared with the VEH (vehicle; saline 10 mL/kg); # p < 0.05 when compared with the HSP-only group.