Table 3.
Associations between clinical parameters at hospitalization and lung diffusion capacity impairment at the follow-up visit.
| DLCO | >80% (n = 450) |
<80% (n = 450) |
OR (univariable) | OR (complete cases) | OR (multiple imputation) |
|---|---|---|---|---|---|
| Predictors | |||||
| Age, years | 56.0 (11.2) | 60.8 (10.9) | 1.53 (1.37–1.73, p < 0.001) | 1.17 (1.02–1.35, p = 0.030) | 1.23 (1.07–1.41, p = 0.004) |
| Sex, woman | 100 (22.2%) | 269 (30.7%) | 1.55 (1.19–2.02, p = 0.001) | 1.87 (1.40–2.50, p < 0.001) | 1.89 (1.42–2.51, p < 0.001) |
| Smoking history | |||||
| Non smoker | 302 (70.6%) | 466 (54.6%) | – | – | – |
| Former | 114 (26.6%) | 343 (40.2%) | 1.95 (1.51–2.53, p < 0.001) | 1.81 (1.37–2.40, p < 0.001) | 1.77 (1.35–2.34, p < 0.001) |
| Current | 12 (2.8%) | 45 (5.3%) | 2.43 (1.31–4.88, p = 0.008) | 2.27 (1.17–4.68, p = 0.020) | 2.19 (1.11–4.32, p = 0.023) |
| NIMV duration, days | 1.1 (3.2) | 1.9 (4.9) | 1.30 (1.11–1.55, p = 0.002) | 1.32 (1.10–1.61, p = 0.004) | 1.25 (1.05–1.49, p = 0.012) |
| IMV duration, days | 8.4 (11.4) | 15.8 (18.6) | 1.79 (1.54–2.11, p < 0.001) | 1.61 (1.33–1.97, p < 0.001) | 1.57 (1.30–1.89, p < 0.001) |
| Infectious complication | 146 (32.4%) | 456 (52.1%) | 2.26 (1.79–2.87, p < 0.001) | 1.20 (0.88–1.63, p = 0.242) | 1.27 (0.94–1.70, p = 0.120) |
| EGFR, mL/min/1.73 m2 | 98.9 (18.5) | 89.7 (23.5) | 0.62 (0.54–0.71, p < 0.001) | 0.73 (0.62–0.86, p < 0.001) | 0.75 (0.65–0.88, p < 0.001) |
| DLCO | >60% (n = 1009) |
<60% (n = 318) |
OR (univariable) | OR (complete cases) | OR (multiple imputation) |
|---|---|---|---|---|---|
| Predictors | |||||
| Age, years | 58.0 (11.2) | 62.9 (10.4) | 1.63 (1.41–1.88, p < 0.001) | 1.36 (1.14–1.62, p = 0.001) | 1.39 (1.18–1.63, p < 0.001) |
| Chronic lung disease | 55 (5.5%) | 43 (13.5%) | 2.71 (1.77–4.12, p < 0.001) | 2.02 (1.25–3.25, p = 0.004) | 1.86 (1.18–2.92, p = 0.007) |
| IMV duration, days | 11.0 (13.9) | 20.5 (22.3) | 1.66 (1.47–1.88, p < 0.001) | 1.57 (1.38–1.79, p < 0.001) | 1.56 (1.37–1.77, p < 0.001) |
| Urea at ICU admission, mg/dL | 42.9 (22.6) | 53.8 (31.9) | 1.48 (1.30–1.69, p < 0.001) | 1.18 (0.98–1.42, p = 0.087) | 1.16 (0.97–1.39, p = 0.106) |
| EGFR, mL/min/1.73 m2 | 95.1 (20.8) | 85.5 (25.2) | 0.67 (0.59–0.75, p < 0.001) | 0.89 (0.73–1.08, p = 0.223) | 0.88 (0.73–1.06, p = 0.182) |
| DLCO (Continuous) | Coefficient (univariable) | Coefficient (complete cases) | Coefficient (multiple imputation) |
|---|---|---|---|
| Predictors | |||
| Age, years | −4.23 (−5.19 to −3.27, p < 0.001) | −2.49 (−3.54 to −1.43, p < 0.001) | −2.51 (−3.55 to −1.46, p < 0.001) |
| IMV duration, days | −4.85 (−5.81 to −3.89, p < 0.001) | −4.22 (−5.16 to −3.28, p < 0.001) | −4.13 (−5.06 to −3.19, p < 0.001) |
| EGFR, mL/min/1.73 m2 | 4.39 (3.43–5.36, p < 0.001) | 2.64 (1.59–3.70, p < 0.001) | 2.61 (1.56–3.67, p < 0.001) |
Abbreviations: DLCO, lung diffusing capacity; NIMV, non-invasive mechanic ventilation; IMV, invasive mechanic ventilation; EGFR, Estimated Glomerular Filtration Rate; ICU, intensive care unit. Note: odds ratios are presented for the 1-SD change of continuous variable. In descriptive data, mean (SD) or n(%) accordingly.