Table 1.
Patient Characteristics Among 155 HDFN Groups, Including Mothers, Neonates, and Fetuses, From 60 Included Studis
| Characteristic | Mean (± SD, Range) | Patient Groups (n) | No. of Studies (References) |
|---|---|---|---|
| Patient group size, n | 36.5 (± 68.7, 1.0–334.0) | 146a | 60 [2, 22–80] |
| Gestational age at birth, weeksb | |||
| Mean gestational age | 35.1 (± 2.1, 33.0–37.4) | 13 | 9 [23, 26, 28, 47, 53, 63, 65, 70, 72] |
| Median gestational age | 35.4 (± 2.1, 28.0–37.0) | 24 | 12 [31, 35, 42, 45, 51, 59, 60, 62, 63, 75, 76] |
| Exact gestational age | 34.1 (± 2.9, 28.1–38.0) | 18 | 14 [22, 24, 27, 34, 39, 43, 44, 46, 50, 52, 55, 66, 74, 77] |
| Gestational age at first IUT, weeks | |||
| Mean gestational age | 26.6 (± 0.1, 26.6–26.7) | 4 | 2 [28, 53] |
| Median gestational age | 25.9 (± 3.4, 21.7–36.3) | 27 | 13 [31, 51, 59–61, 63, 64, 69, 73, 75, 79, 80] |
| Exact gestational age | 24.8 (± 3.9, 20.0–30.1) | 8 | 5 [44, 52, 66, 68, 76] |
Means, medians, and exact gestational age as reported in each study were used to calculate mean (range)
HDFN Hemolytic disease of the fetus and newborn, IUT Intrauterine transfusion
aOf the 155 patient groups, 46 (29.7%) groups were single patients from case reports
bDoes not include 1 study [2] in which the reported percentage of the patient group fell within gestational age ranges (i.e., < 259 days and 259–294 days)