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Effects of plasmid DNA immunization against lethal challenge with P. gingivalis in mice. Female BALB/c mice immunized with plasmid DNA were intraperitoneally challenged with viable P. gingivalis W50 cells (9 × 109 CFU). Intact pSecTag2A and PBS were used as controls. The log rank test was used for calculation of p values. ∗, P = 0.0069; ∗∗, P = 0.0088.
