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. 2023 Jan 6;23:2. doi: 10.1186/s12894-022-01172-8

Table 1.

Demographics, clinicopathologic characteristics, and therapeutic information of the enrolled UTUC patients

Characteristics Received chemotherapy Unreceived chemotherapy Total P value
(N = 4441) (N = 1257) (N = 5698)
Age (years) < 0.001*
 Mean (SD) 72.1 (11.0) 67.2 (10.4) 71.1 (11.1)
Sex 0.076
 Female 1943 (43.8%) 514 (40.9%) 2457 (43.1%)
 Male 2498 (56.2%) 743 (59.1%) 3241 (56.9%)
Race < 0.001*
 White 3887 (87.5%) 1051 (83.6%) 4938 (86.7%)
 Black 185 (4.2%) 53 (4.2%) 238 (4.2%)
 Other 369 (8.3%) 153 (12.2%) 522 (9.2%)
Marital status < 0.001*
 Married 2658 (59.9%) 890 (70.8%) 3548 (62.3%)
 Divorced/widowed/Separated 1363 (30.7%) 248 (19.7%) 1611 (28.3%)
 Unmarried/Single 420 (9.5%) 119 (9.5%) 539 (9.5%)
Primary Site 0.358
 Renal Pelvis 2933 (66.0%) 812 (64.6%) 3745 (65.7%)
 Ureter 1508 (34.0%) 445 (35.4%) 1953 (34.3%)
Grade < 0.001*
 Grade I 246 (5.5%) 21 (1.7%) 267 (4.7%)
 Grade II 801 (18.0%) 77 (6.1%) 878 (15.4%)
 Grade III 1253 (28.2%) 404 (32.1%) 1657 (29.1%)
 Grade IV 2141 (48.2%) 755 (60.1%) 2896 (50.8%)
T Stage < 0.001*
 T1 1642 (37.0%) 177 (14.1%) 1819 (31.9%)
 T2 881 (19.8%) 132 (10.5%) 1013 (17.8%)
 T3 1598 (36.0%) 694 (55.2%) 2292 (40.2%)
 T4 320 (7.2%) 254 (20.2%) 574 (10.1%)
N Stage < 0.001*
 N0 4123 (92.8%) 779 (62.0%) 4902 (86.0%)
 N1 186 (4.2%) 262 (20.8%) 448 (7.9%)
 N2 132 (3.0%) 216 (17.2%) 348 (6.1%)
M Stage < 0.001*
 M0 4286 (96.5%) 1024 (81.5%) 5310 (93.2%)
 M1 155 (3.5%) 233 (18.5%) 388 (6.8%)
Radiation 1.000
 No/Unknown 19 (0.4%) 6 (0.5%) 25 (0.4%)
 Yes 4422 (99.6%) 1251 (99.5%) 5673 (99.6%)
Surgical methods of the primary site < 0.001*
 No 26 (0.6%) 124 (9.9%) 150 (2.6%)
 Local Mass resection/destruction 163 (3.7%) 49 (3.9%) 212 (3.7%)
 Partial nephrectomy/ureterectomy 472 (10.6%) 114 (9.1%) 586 (10.3%)
 Radical nephroureterectomy 2600 (58.5%) 586 (46.6%) 3186 (55.9%)
 Radical nephrectomy 1014 (22.8%) 324 (25.8%) 1338 (23.5%)
 Multivisceral resection 166 (3.7%) 60 (4.8%) 226 (4.0%)
Surgery of Lymph nodes (LNs) < 0.001*
 No 3413 (76.9%) 716 (57.0%) 4129 (72.5%)
 1 to 3 regional LNs removed 610 (13.7%) 268 (21.3%) 878 (15.4%)
 4 or more regional LNs removed 418 (9.4%) 273 (21.7%) 691 (12.1%)

*P < 0.05 indicating statistical significance