Table 3.

Univariate and multivariate COX regression analysis for OS in the training sets

	Univariate analysis			Multivariate analysis
	HR	95%CI	P value	HR	95%CI	P value
Age	1.028	1.02–1.037	< 0.001*	1.027	1.018–1.036	< 0.001*
Sex
Female	Ref
Male	0.949	0.805–1.119	0.532
Race
White	Ref
Black	0.848	0.579–1.241	0.396
Other	1.050	0.823–1.339	0.696
Marital status
Married	Ref
Divorced/widowed/Separated	1.269	1.038–1.549	0.020*	1.114	0.907–1.367	0.302
Unmarried/Single	1.282	0.975–1.685	0.076	1.374	1.039–1.816	0.026*
Primary Site
Renal Pelvis	Ref
Ureter	1.003	0.848–1.186	0.973
Grade
Grade I	Ref
Grade II	1.101	0.545–2.224	0.788
Grade III	1.409	0.746–2.658	0.290
Grade IV	1.161	0.618–2.177	0.642
T Stage
T1	Ref
T2	0.826	0.581–1.172	0.284	1.064	0.744–1.519	0.735
T3	1.084	0.847–1.387	0.520	1.349	1.044–1.743	0.022*
T4	2.405	1.819–3.180	< 0.001*	2.309	1.721–3.097	< 0.001*
N Stage
N0	Ref
N1	1.880	1.542–2.292	< 0.001*	1.284	1.035–1.593	0.023*
N2	2.013	1.633–2.482	< 0.001*	1.354	1.082–1.695	0.008*
M Stage
M0	Ref
M1	3.172	2.609–3.857	< 0.001*	1.985	1.579–2.495	< 0.001*
Radiation
No/Unknown	Ref
Yes	1.241	0.174–8.83	0.829
Surgical methods of the primary site
No	Ref
Local Mass resection/destruction	0.442	0.287–0.679	< 0.001*	0.647	0.412–1.016	0.059
Partial nephrectomy/ureterectomy	0.224	0.156–0.320	< 0.001*	0.445	0.301–0.660	< 0.001*
Radical nephroureterectomy	0.221	0.171–0.284	< 0.001*	0.380	0.283–0.509	< 0.001*
Radical nephrectomy	06.35	0.273–0.464	< 0.001*	0.485	0.364–0.646	< 0.001*
Surgery of Lymph nodes (LNs)
No	Ref
1 to 3 regional LNs removed	0.994	0.810–1.219	0.957
4 or more regional LNs removed	0.830	0.672–1.025	0.083

*P < 0.05 indicating statistical significance