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. 2023 Jan 7;20:6. doi: 10.1186/s12974-023-02690-4

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — SS-31 facilitates functional recovery following SCI. A Photographs of spinal cord sections in the respective groups stained with antibody MAP2 (green) (scale bar = 25 μm). B Photographs of spinal cord sections in the respective groups stained with Syn (green)/NeuN (red) (scale bar = 20 μm). C MAP2 optical density within a spinal cord subjected to injury on day 28. D Relevant quantitative results for motor neuron-contacting synapse amounts on day 28 after SCI. E Longitudinal spinal cord sections from the groups at 28 dpi were examined via HE dyeing and Masson dyeing (scale bar = 1000 μm). F Quantitative investigations of Masson-positive lesions within the spinal cords of the respective groups. G Photographs of mouse footprints on day 28 following SCI. Blue: fore paw print; Red: hind paw print. H, I Toe dragging (%) and stride length (cm) analyses of mice at 28 dpi. J, K Inclined plane test and BMS results for the indicated groups at days 0, 1, 3, 7, 14, 21, and 28. The data are shown as the mean ± SEM. n = 5. *P < 0.05, **P < 0.01. ns indicates no significance