Table 2.

Seroprevalence in different groups (CVA6)

Variable	Ref (n)	n	Events	Transformation method	Seroprevalence (%)	95% CI (%)	I2 (%)	Heterogeneity (P-value)	Begg’s (P-value)	Egger’s (P-value)
Total	8	2522	4079	Random-effects model	0.583	0.465, 0.702	98.6	<0.001	0.016	0.056
Age
<1 y	5	192	406	Freeman-Tukey double arcsine	0.43	0.24, 0.63	95.01	<0.001
1-3 y	4	269	582	Random-effects model	0.425	0.307, 0.542	88.1	<0.001
3-5 y	2	143	207	Random-effects model	0.686	0.490, 0.882	89.9	<0.001
<5 y	8	839	1564	Random-effects model	0.558	0.476, 0.640	90.4	<0.001
>5 y	6	1989	2760	Freeman-Tukey double arcsine	0.72	0.61, 0.82	97.74	<0.001
Gender
Female	3	415	759	Random-effects model	0.554	0.425, 0.683	91.7	<0.001
Male	3	334	627	Random-effects model	0.541	0.328, 0.754	96.5	<0.001
Sampling method
Physical examination	2	546	871	Fixed- effects model	0.627	0.595, 0.659	0.0	0.973
Random sampling	2	501	1003	Random-effects model	0.502	0.290, 0.715	98.0	<0.001
Conditional sampling	4	1475	2205	Random-effects model	0.595	0.421, 0.770	99.0	<0.001
Seasonality
Seasonal	4	362	868	Random-effects model	0.440	0.310, 0.571	93.7	<0.001
Non-seasonal	1	439	700	Random-effects model	0.627	0.591, 0.663	-	-
Unknown	3	1721	2511	Freeman-Tukey double arcsine	0.69	0.52, 0.84	98.75	<0.001
Publication language
English	6	2341	3727	Random-effects model	0.599	0.465, 0.733	98.9	<0.001
Chinese	2	181	352	Random-effects model	0.517	0.305, 0.730	94.3	<0.001
Ethnicity
Chinese	5	757	1535	Random-effects model	0.491	0.383, 0.599	94.4	<0.001
Other	3	1765	2544	Freeman-Tukey double arcsine	0.68	0.51, 0.83	98.78	<0.001