Table 3.

Seroprevalence in different groups (EV-A71)

Variable	Ref(n)	n	Event	Transformation Method	Seroprevalence (%)	95% CI (%)	I2 (%)	Heterogeneity (P-value)	Begg’s (P-value)	Egger’s (P-value)
Total	78	52654	23297	Random-effects model	0.459	0.376,0.541	99.9	< 0.001	0.0001	0.271
Age
<1 yrs	36	5980	1716	Freeman-Tukey double arcsine	0.28	0.22,0.35	95.80	< 0.001
1-3 yrs	34	5570	1766	Random-effects model	0.327	0.271,0.382	96.2	< 0.001
3-5 yrs	29	3580	1601	Random-effects model	0.502	0.436,0.568	94.6	< 0.001
<5 yrs	56	6713	19777	Random-effects model	0.363	0.320,0.406	98.1	< 0.001
>5 yrs	40	8866	14387	Freeman-Tukey double arcsine	0.62	0.56,0.68	98.07	< 0.001
Gender
Female	17	2511	5026	Random-effects model	0.439	0.338,0.540	98.5	< 0.001
Male	17	2712	5640	Random-effects model	0.44	0.365,0.516	97.3	< 0.001
Sampling method
Physical examination	9	2380	6961	Random-effects model	0.367	0.299,0.434	97.4	< 0.001
Random sampling	41	12542	24843	Random-effects model	0.478	0.397,0.559	99.6	< 0.001
Conditional sampling	13	3428	12912	Freeman-Tukey double arcsine	0.43	0.21,0.67	99.84	< 0.001
Seasonality
Season	35	11141	21373	Random-effects model	0.476	0.393,0.558	99.5	< 0.001
Non-season	8	3094	8673	Freeman-Tukey double arcsine	0.36	0.21,0.52	99.58	< 0.001
Unknown	19	4115	14670	Random-effects model	0.450	0.300,0.599	99.8	< 0.001
Publication language
English	46	18649	43952	Random-effects model	0.442	0.347,0.536	99.9	< 0.001
Chinese	19	4940	9453	Random-effects model	0.502	0.429,0.575	98.2	< 0.001
Ethnicity
Chinese	49	18256	33962	Random-effects model	0.478	0.424,0.532	99.2	< 0.001
Others	17	5041	18692	Freeman-Tukey double arcsine	0.38	0.23,0.55	99.79	< 0.001