Table 3.

Fibroglandular and fatty breast tissue in 97 premenopausal women treated with isoflavones and 97 with placebo compared by intention-to-treat analysis

		FGBT (cc)*			FBT (cc)*			FGBT%*
Model	Effect‡,§	β-Estimate (SE)		p value	β-Estimate (SE)		p value	β-Estimate (SE)		p value
1	Treatment	0.085	(0.470)	0.856	−0.318	(1.135)	0.780	0.070	(0.196)	0.721
	Duration	0.161	(0.083)	0.054	−0.062	(0.174)	0.720	0.034	(0.035)	0.331
	Treatment × Duration	−0.184	(0.118)	0.122	0.379	(0.247)	0.125	−0.101	(0.049)	0.040
2	Treatment	0.075	(0.470)	0.873	−0.267	(1.133)	0.814	0.060	(0.195)	0.758
	Duration	0.141	(0.086)	0.101	0.022	(0.173)	0.900	0.016	(0.035)	0.653
	Treatment × Duration	−0.188	(0.118)	0.113	0.385	(0.240)	0.109	−0.104	(0.048)	0.032
	Ca2+	0.265	(0.252)	0.295	−1.017	(0.469)	0.031	0.225	(0.102)	0.028
3	Treatment	0.117	(0.472)	0.805	−0.466	(1.130)	0.681	0.103	(0.195)	0.597
	Duration	0.159	(0.087)	0.069	−0.063	(0.173)	0.716	0.034	(0.035)	0.325
	Treatment × Duration	−0.238	(0.126)	0.061	0.620	(0.250)	0.014	−0.155	(0.051)	0.003
	Ca2+	0.030	(0.328)	0.928	0.068	(0.600)	0.910	−0.017	(0.131)	0.894
	Treatment × Ca2+	0.570	(0.511)	0.266	−2.705	(0.944)	0.005	0.588	(0.204)	0.004
4†	Treatment	0.084	(0.462)	0.857	0.505	(0.670)	0.452	−0.022	(0.160)	0.891
	Duration	0.157	(0.087)	0.072	−0.216	(0.121)	0.076	0.057	(0.031)	0.067
	Treatment × Duration	−0.258	(0.126)	0.042	0.248	(0.176)	0.160	−0.107	(0.045)	0.019
	Ca2+	−0.028	(0.329)	0.932	−0.058	(0.460)	0.423	−0.029	(0.118)	0.807
	Treatment × Ca2+	0.717	(0.514)	0.164	−1.223	(0.718)	0.090	0.388	(0.184)	0.035
	BMI	0.038	(0.033)	0.254	1.079	(0.048)	< 0.001	−0.141	(0.012)	< 0.001

^*Fibroglandular breast tissue expressed as volume (FGBT) or percent of total breast tissue (FGBT%) and fatty breast tissue as volume (FBT). Regression coefficient (β-Estimate), corresponding standard error (SE), and p value are for square-root transformed outcomes.

^†Model 4 also included age at entry to the study and race.

^‡Duration expressed in years.

^§Serum Ca²⁺ is mean-centered.