Table 1. Hemoglobinopathy variant comparison.

	Heterozygous	Homozygous or multiple hemoglobinopathies
Age of Presentation	Typically asymptomatic	3-6 months
Clinical Features	If symptomatic: Painless hematuria, hyposthenuria, vaso-occlusive events with severe oxygen deficiency	Vaso-occlusive crisis, dactylitis, stroke, acute chest syndrome, acute hemolytic crisis
RBC Morphology	If symptomatic: drepanocytes, target cells, Howell-Jolly bodies	Drepanocytes, target cells, Howell-Jolly bodies